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First-in-human study to investigate the safety and efficacy of effective-mononuclear cell therapy for radiogenic xerostomia.

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Title: First-in-human study to investigate the safety and efficacy of effective-mononuclear cell therapy for radiogenic xerostomia.
Authors: I T; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Iwatake M; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Research Institute for Quantum and Chemical Innovation, Institutes of Innovation for Future Society, Nagoya University, Nagoya, Japan., Yoshida T; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Nagai K; Transfusion and Cell Therapy Unit, Nagasaki University Hospital, Nagasaki, Japan., Hotokezaka Y; Department of Orthodontics and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Nishihara M; CellAxia Inc., Tokyo, Japan., Honma R; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Harada H; Transfusion and Cell Therapy Unit, Nagasaki University Hospital, Nagasaki, Japan., Hayashida M; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Nagano T; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Kanai R; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Ohba S; Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Oral and Maxillofacial Surgery, Showa Medical University School of Dentistry, Tokyo, Japan., Yoshimura A; Department of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Masuda H; Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kanagawa, Japan., Asahara T; Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kanagawa, Japan., Miyazaki Y; Transfusion and Cell Therapy Unit, Nagasaki University Hospital, Nagasaki, Japan.; Department of Hematology, Atomic Bomb Disease Research Institute, Nagasaki University, Nagasaki, Japan., Kawakami A; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Asahina I; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of oral surgery, Faculty of Medicine, Juntendo university, Tokyo, Japan., Seki M; CellAxia Inc., Tokyo, Japan., Sumita Y; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Source: Regenerative therapy [Regen Ther] 2026 Jan 10; Vol. 31, pp. 101059. Date of Electronic Publication: 2026 Jan 10 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: The Japanese Society for Regenerative Medicine. Production and Hosting by Elsevier B.V Country of Publication: Netherlands NLM ID: 101709085 Publication Model: eCollection Cited Medium: Internet ISSN: 2352-3204 (Electronic) Linking ISSN: 23523204 NLM ISO Abbreviation: Regen Ther Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: First-in-human study to investigate the safety and efficacy of effective-mononuclear cell therapy for radiogenic xerostomia.
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  Data: <searchLink fieldCode="AU" term="%22I+T%22">I T</searchLink>; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Iwatake+M%22">Iwatake M</searchLink>; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Research Institute for Quantum and Chemical Innovation, Institutes of Innovation for Future Society, Nagoya University, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshida+T%22">Yoshida T</searchLink>; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Nagai+K%22">Nagai K</searchLink>; Transfusion and Cell Therapy Unit, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Hotokezaka+Y%22">Hotokezaka Y</searchLink>; Department of Orthodontics and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Nishihara+M%22">Nishihara M</searchLink>; CellAxia Inc., Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Honma+R%22">Honma R</searchLink>; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Harada+H%22">Harada H</searchLink>; Transfusion and Cell Therapy Unit, Nagasaki University Hospital, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Hayashida+M%22">Hayashida M</searchLink>; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Nagano+T%22">Nagano T</searchLink>; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Kanai+R%22">Kanai R</searchLink>; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Ohba+S%22">Ohba S</searchLink>; Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Oral and Maxillofacial Surgery, Showa Medical University School of Dentistry, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshimura+A%22">Yoshimura A</searchLink>; Department of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Masuda+H%22">Masuda H</searchLink>; Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Asahara+T%22">Asahara T</searchLink>; Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Miyazaki+Y%22">Miyazaki Y</searchLink>; Transfusion and Cell Therapy Unit, Nagasaki University Hospital, Nagasaki, Japan.; Department of Hematology, Atomic Bomb Disease Research Institute, Nagasaki University, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Kawakami+A%22">Kawakami A</searchLink>; Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Asahina+I%22">Asahina I</searchLink>; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of oral surgery, Faculty of Medicine, Juntendo university, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Seki+M%22">Seki M</searchLink>; CellAxia Inc., Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sumita+Y%22">Sumita Y</searchLink>; Department of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.; Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101709085%22">Regenerative therapy</searchLink> [Regen Ther] 2026 Jan 10; Vol. 31, pp. 101059. <i>Date of Electronic Publication: </i>2026 Jan 10 (<i>Print Publication: </i>2026).
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        Value: 10.1016/j.reth.2025.101059
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        Text: English
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              Text: 2026 Jan 10
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