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Translating spatial transcriptomic signatures in adenosquamous carcinoma into bulk prognostic biomarkers in lung adenocarcinoma: a bottom-up approach.

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Title: Translating spatial transcriptomic signatures in adenosquamous carcinoma into bulk prognostic biomarkers in lung adenocarcinoma: a bottom-up approach.
Authors: Hatakeyama K; Cancer Multiomics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan. k.hatakeyama@scchr.jp., Kawata T; Division of Pathology, Shizuoka Cancer Center Hospital, Sunto-gun, Shizuoka, Japan., Muramatsu K; Division of Pathology, Shizuoka Cancer Center Hospital, Sunto-gun, Shizuoka, Japan., Oishi T; Division of Pathology, Shizuoka Cancer Center Hospital, Sunto-gun, Shizuoka, Japan., Nagashima T; Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.; SRL Inc., Shinjuku-ku, Tokyo, Japan., Sakai A; SRL Inc., Shinjuku-ku, Tokyo, Japan., Nishimura T; Cancer Multiomics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan., Ohshima K; Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan., Ohnami S; Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan., Ohnami S; Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan., Shimoda Y; Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan., Naruoka A; Drug Discovery and Development Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan., Maruyama K; Experimental Animal Facility, Shizuoka Cancer Center Research Institute, Shizuoka, Japan., Urakami K; Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan., Akiyama Y; Immunotherapy Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan., Ohde Y; Division of Thoracic Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan., Sugino T; Division of Pathology, Shizuoka Cancer Center Hospital, Sunto-gun, Shizuoka, Japan., Yamaguchi K; Shizuoka Cancer Center, Shizuoka, Japan.
Source: NPJ precision oncology [NPJ Precis Oncol] 2026 Jan 23; Vol. 10 (1). Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
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  Data: Translating spatial transcriptomic signatures in adenosquamous carcinoma into bulk prognostic biomarkers in lung adenocarcinoma: a bottom-up approach.
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  Data: <searchLink fieldCode="AU" term="%22Hatakeyama+K%22">Hatakeyama K</searchLink>; Cancer Multiomics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan. k.hatakeyama@scchr.jp.<br /><searchLink fieldCode="AU" term="%22Kawata+T%22">Kawata T</searchLink>; Division of Pathology, Shizuoka Cancer Center Hospital, Sunto-gun, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Muramatsu+K%22">Muramatsu K</searchLink>; Division of Pathology, Shizuoka Cancer Center Hospital, Sunto-gun, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Oishi+T%22">Oishi T</searchLink>; Division of Pathology, Shizuoka Cancer Center Hospital, Sunto-gun, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Nagashima+T%22">Nagashima T</searchLink>; Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.; SRL Inc., Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sakai+A%22">Sakai A</searchLink>; SRL Inc., Shinjuku-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimura+T%22">Nishimura T</searchLink>; Cancer Multiomics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Ohshima+K%22">Ohshima K</searchLink>; Medical Genetics Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Ohnami+S%22">Ohnami S</searchLink>; Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Ohnami+S%22">Ohnami S</searchLink>; Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Shimoda+Y%22">Shimoda Y</searchLink>; Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Naruoka+A%22">Naruoka A</searchLink>; Drug Discovery and Development Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Maruyama+K%22">Maruyama K</searchLink>; Experimental Animal Facility, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Urakami+K%22">Urakami K</searchLink>; Cancer Diagnostics Research Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Akiyama+Y%22">Akiyama Y</searchLink>; Immunotherapy Division, Shizuoka Cancer Center Research Institute, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Ohde+Y%22">Ohde Y</searchLink>; Division of Thoracic Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Sugino+T%22">Sugino T</searchLink>; Division of Pathology, Shizuoka Cancer Center Hospital, Sunto-gun, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+K%22">Yamaguchi K</searchLink>; Shizuoka Cancer Center, Shizuoka, Japan.
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