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CHI3L1 monoclonal antibody therapy mitigates cognitive impairment by inhibiting neuroinflammation through ERK and NF-κB pathway in Tg2576 mice.

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Title: CHI3L1 monoclonal antibody therapy mitigates cognitive impairment by inhibiting neuroinflammation through ERK and NF-κB pathway in Tg2576 mice.
Authors: Ham HJ; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea., Park SS; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea., Lee YS; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea., Kim TH; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea., Son DJ; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea., Kim JH; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea., Lim KH; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea., Park H; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea., Lee HJ; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea., Yun J; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea., Han SB; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea., Choi MK; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea., Hong JT; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.
Source: Frontiers in molecular neuroscience [Front Mol Neurosci] 2026 Jan 07; Vol. 18, pp. 1728279. Date of Electronic Publication: 2026 Jan 07 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477914 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5099 (Print) Linking ISSN: 16625099 NLM ISO Abbreviation: Front Mol Neurosci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: CHI3L1 monoclonal antibody therapy mitigates cognitive impairment by inhibiting neuroinflammation through ERK and NF-κB pathway in Tg2576 mice.
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  Data: <searchLink fieldCode="AU" term="%22Ham+HJ%22">Ham HJ</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+SS%22">Park SS</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+YS%22">Lee YS</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+TH%22">Kim TH</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Son+DJ%22">Son DJ</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+JH%22">Kim JH</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lim+KH%22">Lim KH</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+H%22">Park H</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+HJ%22">Lee HJ</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yun+J%22">Yun J</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Han+SB%22">Han SB</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+MK%22">Choi MK</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Hong+JT%22">Hong JT</searchLink>; College of Pharmacy and Medical Research Center, Chungbuk National University, Cheongju, North Chungcheong, Republic of Korea.
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  Data: <searchLink fieldCode="JN" term="%22101477914%22">Frontiers in molecular neuroscience</searchLink> [Front Mol Neurosci] 2026 Jan 07; Vol. 18, pp. 1728279. <i>Date of Electronic Publication: </i>2026 Jan 07 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation%22">Frontiers Research Foundation </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101477914 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1662-5099 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216625099%22">16625099 </searchLink><i>NLM ISO Abbreviation: </i>Front Mol Neurosci <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Jan 07
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