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In vitro and in vivo antimicrobial activity of protoberberine alkaloids as novel therapeutic candidates against Mycoplasma hyopneumoniae.

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Title: In vitro and in vivo antimicrobial activity of protoberberine alkaloids as novel therapeutic candidates against Mycoplasma hyopneumoniae.
Authors: Wang C; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China., He X; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China., Yang L; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China., Qian Y; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China., Li X; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China., Duan X; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China., Ma H; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China., Zhang Z; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China., Wang X; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China., Tan C; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.; Hubei Hongshan Laboratory, Wuhan, Hubei, China.; Frontiers Science Center for Animal Breeding and Sustainable Production, Wuhan, Hubei, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Wuhan, Hubei, China.; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, Hubei, China.
Source: Microbiology spectrum [Microbiol Spectr] 2026 Mar 03; Vol. 14 (3), pp. e0325425. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In vitro and in vivo antimicrobial activity of protoberberine alkaloids as novel therapeutic candidates against Mycoplasma hyopneumoniae.
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  Data: <searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22He+X%22">He X</searchLink>; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Qian+Y%22">Qian Y</searchLink>; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Duan+X%22">Duan X</searchLink>; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Ma+H%22">Ma H</searchLink>; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Tan+C%22">Tan C</searchLink>; National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.; Hubei Hongshan Laboratory, Wuhan, Hubei, China.; Frontiers Science Center for Animal Breeding and Sustainable Production, Wuhan, Hubei, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Wuhan, Hubei, China.; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, Hubei, China.
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  Data: <searchLink fieldCode="JN" term="%22101634614%22">Microbiology spectrum</searchLink> [Microbiol Spectr] 2026 Mar 03; Vol. 14 (3), pp. e0325425. <i>Date of Electronic Publication: </i>2026 Jan 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22ASM+Press%22">ASM Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101634614 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2165-0497 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221650497%22">21650497 </searchLink><i>NLM ISO Abbreviation: </i>Microbiol Spectr <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41575198
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        Value: 10.1128/spectrum.03254-25
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      – Code: eng
        Text: English
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      – TitleFull: In vitro and in vivo antimicrobial activity of protoberberine alkaloids as novel therapeutic candidates against Mycoplasma hyopneumoniae.
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            – D: 03
              M: 03
              Text: 2026 Mar 03
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              Y: 2026
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