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ICG-001 Provides Cardioprotection Against Doxorubicin-Induced Cardiotoxicity and Enhances Cancer Cytotoxicity.

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Title: ICG-001 Provides Cardioprotection Against Doxorubicin-Induced Cardiotoxicity and Enhances Cancer Cytotoxicity.
Authors: Wu B; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, China., Chen JCH; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Ma CHY; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Kwok M; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong, Hong Kong SAR, China., Chan VT; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Sung CC; Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Song Y; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China., Zhang T; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China., Lam HS; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Meng F; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; Department of Biology and Center for Genomics and Systems Biology, New York University, New York, New York, USA., Liang Y; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Tsoi C; Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong, Hong Kong SAR, China; Centre for Cardiovascular Genomics and Medicine, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Deng R; Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong, Hong Kong SAR, China; Centre for Cardiovascular Genomics and Medicine, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Tsui SKW; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Leung KT; Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong, Hong Kong SAR, China; The Department of Paediatrics The Chinese University of Hong Kong, Hong Kong SAR, China., Wang CC; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong, Hong Kong SAR, China; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Chan GCF; The Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China., Boheler KR; The Department of Biomedical Engineering and the Department of Medicine/Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA., Chung KKK; Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Poon EN; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong, Hong Kong SAR, China; Centre for Cardiovascular Genomics and Medicine, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; Ministry of Education Key Laboratory for Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: ellen.poon@cuhk.edu.hk.
Source: JACC. Basic to translational science [JACC Basic Transl Sci] 2026 Feb; Vol. 11 (2), pp. 101459. Date of Electronic Publication: 2026 Jan 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: ICG-001 Provides Cardioprotection Against Doxorubicin-Induced Cardiotoxicity and Enhances Cancer Cytotoxicity.
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  Data: <searchLink fieldCode="AU" term="%22Wu+B%22">Wu B</searchLink>; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, China.<br /><searchLink fieldCode="AU" term="%22Chen+JCH%22">Chen JCH</searchLink>; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Ma+CHY%22">Ma CHY</searchLink>; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Kwok+M%22">Kwok M</searchLink>; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Chan+VT%22">Chan VT</searchLink>; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Sung+CC%22">Sung CC</searchLink>; Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Lam+HS%22">Lam HS</searchLink>; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Meng+F%22">Meng F</searchLink>; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; Department of Biology and Center for Genomics and Systems Biology, New York University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Tsoi+C%22">Tsoi C</searchLink>; Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong, Hong Kong SAR, China; Centre for Cardiovascular Genomics and Medicine, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Deng+R%22">Deng R</searchLink>; Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong, Hong Kong SAR, China; Centre for Cardiovascular Genomics and Medicine, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Tsui+SKW%22">Tsui SKW</searchLink>; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Leung+KT%22">Leung KT</searchLink>; Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong, Hong Kong SAR, China; The Department of Paediatrics The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Wang+CC%22">Wang CC</searchLink>; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong, Hong Kong SAR, China; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Chan+GCF%22">Chan GCF</searchLink>; The Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Boheler+KR%22">Boheler KR</searchLink>; The Department of Biomedical Engineering and the Department of Medicine/Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Chung+KKK%22">Chung KKK</searchLink>; Division of Life Science, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Poon+EN%22">Poon EN</searchLink>; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong, Hong Kong SAR, China; Centre for Cardiovascular Genomics and Medicine, Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; Ministry of Education Key Laboratory for Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: ellen.poon@cuhk.edu.hk.
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  Data: <searchLink fieldCode="JN" term="%22101677259%22">JACC. Basic to translational science</searchLink> [JACC Basic Transl Sci] 2026 Feb; Vol. 11 (2), pp. 101459. <i>Date of Electronic Publication: </i>2026 Jan 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+on+behalf+of+the+American+College+of+Cardiology+Foundation%22">Elsevier on behalf of the American College of Cardiology Foundation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101677259 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2452-302X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222452302X%22">2452302X </searchLink><i>NLM ISO Abbreviation: </i>JACC Basic Transl Sci <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Feb
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