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Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1Glu280Ala mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial.

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Title: Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1Glu280Ala mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial.
Authors: Tariot PN; Banner Alzheimer's Institute, Phoenix, AZ, USA. Electronic address: pierre.tariot@bannerhealth.com., Lopera FS; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Ríos-Romenets S; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Sink KM; Genentech, San Francisco, CA, USA., Giraldo-Chica M; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Acosta-Baena N; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Villegas G; University of Antioquia, Medellín, Colombia., Espinosa A; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia; Hospital San Juan de Dios de Yarumal, Antioquia, Colombia., Castaño ML; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Muñoz C; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Ospina P; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Bocanegra Y; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Tirado V; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Henao E; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Cardona E; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Luna E; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Lopez H; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Sánchez G; Cardiomet Cequin, Universidad del Quindío, Armenia, Colombia; San Juan de Dios Hospital, Armenia, Colombia., Collazos MM; Marly's Clinic, Bogotá, Colombia., Alvarez S; Hospital Pablo Tobón Uribe, Medellín, Colombia., Aguillón D; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia., Hu N; Genentech, San Francisco, CA, USA., Clayton D; Genentech, San Francisco, CA, USA., Bittner T; Genentech, San Francisco, CA, USA; F Hoffmann-La Roche, Basel, Switzerland., Schneider A; F Hoffmann-La Roche, Basel, Switzerland., Dolton M; Genentech, San Francisco, CA, USA., Poon V; Genentech, San Francisco, CA, USA., Nguyen J; Genentech, San Francisco, CA, USA., Thomas RG; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA, USA., Schneider LS; Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA., Chen K; Banner Alzheimer's Institute, Phoenix, AZ, USA., Su Y; Banner Alzheimer's Institute, Phoenix, AZ, USA., Alexander RC; Banner Alzheimer's Institute, Phoenix, AZ, USA., Quiroz YT; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia; Departments of Psychiatry and Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA., Cai Y; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Xu YR; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ostaszewski B; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Selkoe DJ; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ashton NJ; Banner Alzheimer's Institute, Phoenix, AZ, USA; Banner Sun Health Research Institute, Sun City, AZ, USA; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Denkinger MN; Banner Sun Health Research Institute, Sun City, AZ, USA., Jakimovich LJ; Banner Alzheimer's Institute, Phoenix, AZ, USA., Doody RS; Genentech, San Francisco, CA, USA; F Hoffmann-La Roche, Basel, Switzerland., Langbaum JB; Banner Alzheimer's Institute, Phoenix, AZ, USA., Reiman EM; Banner Alzheimer's Institute, Phoenix, AZ, USA.
Source: The Lancet. Neurology [Lancet Neurol] 2026 Feb; Vol. 25 (2), pp. 147-159.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 101139309 Publication Model: Print Cited Medium: Internet ISSN: 1474-4465 (Electronic) Linking ISSN: 14744422 NLM ISO Abbreviation: Lancet Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1<superscript>Glu280Ala</superscript> mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Tariot+PN%22">Tariot PN</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA. Electronic address: pierre.tariot@bannerhealth.com.<br /><searchLink fieldCode="AU" term="%22Lopera+FS%22">Lopera FS</searchLink>; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Ríos-Romenets+S%22">Ríos-Romenets S</searchLink>; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Sink+KM%22">Sink KM</searchLink>; Genentech, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Giraldo-Chica+M%22">Giraldo-Chica M</searchLink>; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Acosta-Baena+N%22">Acosta-Baena N</searchLink>; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Villegas+G%22">Villegas G</searchLink>; University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Espinosa+A%22">Espinosa A</searchLink>; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia; Hospital San Juan de Dios de Yarumal, Antioquia, Colombia.<br /><searchLink fieldCode="AU" term="%22Castaño+ML%22">Castaño ML</searchLink>; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Muñoz+C%22">Muñoz C</searchLink>; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Ospina+P%22">Ospina P</searchLink>; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Bocanegra+Y%22">Bocanegra Y</searchLink>; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Tirado+V%22">Tirado V</searchLink>; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia.<br /><searchLink fieldCode="AU" term="%22Henao+E%22">Henao E</searchLink>; 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Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Su+Y%22">Su Y</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Alexander+RC%22">Alexander RC</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Quiroz+YT%22">Quiroz YT</searchLink>; Neuroscience Group of Antioquia (GNA), University of Antioquia, Medellín, Colombia; Departments of Psychiatry and Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+YR%22">Xu YR</searchLink>; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ostaszewski+B%22">Ostaszewski B</searchLink>; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Selkoe+DJ%22">Selkoe DJ</searchLink>; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ashton+NJ%22">Ashton NJ</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA; Banner Sun Health Research Institute, Sun City, AZ, USA; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Denkinger+MN%22">Denkinger MN</searchLink>; Banner Sun Health Research Institute, Sun City, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Jakimovich+LJ%22">Jakimovich LJ</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Doody+RS%22">Doody RS</searchLink>; Genentech, San Francisco, CA, USA; F Hoffmann-La Roche, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Langbaum+JB%22">Langbaum JB</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Reiman+EM%22">Reiman EM</searchLink>; Banner Alzheimer's Institute, Phoenix, AZ, USA.
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