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Novel imidazolium salts bearing 2-oxindoles scaffold as potent acetylcholinesterase inhibitors for Alzheimer's disease: Design, synthesis, in vitro and in silico studies.

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Title: Novel imidazolium salts bearing 2-oxindoles scaffold as potent acetylcholinesterase inhibitors for Alzheimer's disease: Design, synthesis, in vitro and in silico studies.
Authors: Tien LQ; Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 11021, Viet Nam., Phung HTT; Faculty of Chemistry, VNU - University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi 11021, Viet Nam., Do HH; Faculty of Chemistry, VNU - University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi 11021, Viet Nam., Khac TN; Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 11021, Viet Nam., Minh PTN; Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 11021, Viet Nam., Linh VNH; Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 11021, Viet Nam., Thang NQ; Radiology and Nuclear Medicine Department, Vinmec Times City International Hospital, Vinmec Health Care System, Hanoi 100000, Viet Nam., Wang S; Department of Chemistry, Engineering Center of Catalysis and Synthesis for Chiral Molecules, Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs, State Key Laboratory of Green Chemical Synthesis and Conversion, Fudan University, Shanghai, China., Tran PT; Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 11021, Viet Nam. Electronic address: thaotp119@gmail.com.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2026 May; Vol. 134, pp. 130560. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Novel imidazolium salts bearing 2-oxindoles scaffold as potent acetylcholinesterase inhibitors for Alzheimer's disease: Design, synthesis, in vitro and in silico studies.
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  Data: <searchLink fieldCode="AU" term="%22Tien+LQ%22">Tien LQ</searchLink>; Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 11021, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Phung+HTT%22">Phung HTT</searchLink>; Faculty of Chemistry, VNU - University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi 11021, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Do+HH%22">Do HH</searchLink>; Faculty of Chemistry, VNU - University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi 11021, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Khac+TN%22">Khac TN</searchLink>; Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 11021, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Minh+PTN%22">Minh PTN</searchLink>; Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 11021, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Linh+VNH%22">Linh VNH</searchLink>; Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 11021, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Thang+NQ%22">Thang NQ</searchLink>; Radiology and Nuclear Medicine Department, Vinmec Times City International Hospital, Vinmec Health Care System, Hanoi 100000, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Chemistry, Engineering Center of Catalysis and Synthesis for Chiral Molecules, Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs, State Key Laboratory of Green Chemical Synthesis and Conversion, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Tran+PT%22">Tran PT</searchLink>; Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi 11021, Viet Nam. Electronic address: thaotp119@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2026 May; Vol. 134, pp. 130560. <i>Date of Electronic Publication: </i>2026 Jan 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bmcl.2026.130560
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      – Code: eng
        Text: English
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        StartPage: 130560
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      – TitleFull: Novel imidazolium salts bearing 2-oxindoles scaffold as potent acetylcholinesterase inhibitors for Alzheimer's disease: Design, synthesis, in vitro and in silico studies.
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              M: 05
              Text: 2026 May
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              Y: 2026
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