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Epigenetic alterations of AKT1 orchestrate a metabolic reprogramming in advanced lipedema: translational insights from an integrated multi-omics study.

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Title: Epigenetic alterations of AKT1 orchestrate a metabolic reprogramming in advanced lipedema: translational insights from an integrated multi-omics study.
Authors: Santella B; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Salerno, 84081, Italy.; National Biodiversity Future Center (NBFC), Palermo, 90133, Italy., Salvati A; Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Salerno, Italy.; Postgraduate School in Clinical Pathology and Clinical Biochemistry, University of Salerno, Baronissi, Salerno, Italy., Papp A; P-Health Medical Solution, F.-W.-Raiffeisenstraße 1b, Elsbethen, Salzburg, 5061, Austria., D'Ursi A; National Biodiversity Future Center (NBFC), Palermo, 90133, Italy.; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, Salerno, 84084, Italy., Memoli D; Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Salerno, Italy., Mingo M; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Salerno, 84081, Italy., Pulai C; P-Health Medical Solution, F.-W.-Raiffeisenstraße 1b, Elsbethen, Salzburg, 5061, Austria., Marino C; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, Salerno, 84084, Italy., Rastrelli L; National Biodiversity Future Center (NBFC), Palermo, 90133, Italy.; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, Salerno, 84084, Italy., D'Elia M; National Biodiversity Future Center (NBFC), Palermo, 90133, Italy.; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, Salerno, 84084, Italy., Nassa G; Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Salerno, Italy. gnassa@unisa.it.; Genome Research Center for Health - CRGS, Baronissi, Salerno, Italy. gnassa@unisa.it.; Molecular Pathology and Medical Genomics Unit, AOU 'S. Giovanni di Dio e Ruggi d'Aragona', University of Salerno, Salerno, Italy. gnassa@unisa.it., Schiavo L; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Salerno, 84081, Italy. lschiavo@unisa.it.; National Biodiversity Future Center (NBFC), Palermo, 90133, Italy. lschiavo@unisa.it.
Source: Journal of translational medicine [J Transl Med] 2026 Jan 24; Vol. 24 (1), pp. 265. Date of Electronic Publication: 2026 Jan 24.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Santella+B%22">Santella B</searchLink>; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Salerno, 84081, Italy.; National Biodiversity Future Center (NBFC), Palermo, 90133, Italy.<br /><searchLink fieldCode="AU" term="%22Salvati+A%22">Salvati A</searchLink>; Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Salerno, Italy.; Postgraduate School in Clinical Pathology and Clinical Biochemistry, University of Salerno, Baronissi, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Papp+A%22">Papp A</searchLink>; P-Health Medical Solution, F.-W.-Raiffeisenstraße 1b, Elsbethen, Salzburg, 5061, Austria.<br /><searchLink fieldCode="AU" term="%22D'Ursi+A%22">D'Ursi A</searchLink>; National Biodiversity Future Center (NBFC), Palermo, 90133, Italy.; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, Salerno, 84084, Italy.<br /><searchLink fieldCode="AU" term="%22Memoli+D%22">Memoli D</searchLink>; Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Salerno, Italy.<br /><searchLink fieldCode="AU" term="%22Mingo+M%22">Mingo M</searchLink>; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Salerno, 84081, Italy.<br /><searchLink fieldCode="AU" term="%22Pulai+C%22">Pulai C</searchLink>; P-Health Medical Solution, F.-W.-Raiffeisenstraße 1b, Elsbethen, Salzburg, 5061, Austria.<br /><searchLink fieldCode="AU" term="%22Marino+C%22">Marino C</searchLink>; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, Salerno, 84084, Italy.<br /><searchLink fieldCode="AU" term="%22Rastrelli+L%22">Rastrelli L</searchLink>; National Biodiversity Future Center (NBFC), Palermo, 90133, Italy.; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, Salerno, 84084, Italy.<br /><searchLink fieldCode="AU" term="%22D'Elia+M%22">D'Elia M</searchLink>; National Biodiversity Future Center (NBFC), Palermo, 90133, Italy.; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, Salerno, 84084, Italy.<br /><searchLink fieldCode="AU" term="%22Nassa+G%22">Nassa G</searchLink>; Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Salerno, Italy. gnassa@unisa.it.; Genome Research Center for Health - CRGS, Baronissi, Salerno, Italy. gnassa@unisa.it.; Molecular Pathology and Medical Genomics Unit, AOU 'S. Giovanni di Dio e Ruggi d'Aragona', University of Salerno, Salerno, Italy. gnassa@unisa.it.<br /><searchLink fieldCode="AU" term="%22Schiavo+L%22">Schiavo L</searchLink>; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Baronissi, Salerno, 84081, Italy. lschiavo@unisa.it.; National Biodiversity Future Center (NBFC), Palermo, 90133, Italy. lschiavo@unisa.it.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 Jan 24; Vol. 24 (1), pp. 265. <i>Date of Electronic Publication: </i>2026 Jan 24.
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