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SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity.

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Title: SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity.
Authors: Zhong Y; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Mazik L; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Su H; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Chiang CY; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Geng F; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Mo X; Department of Biomedical Informatics, The Center for Biostatistics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA., Wang Q; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Kou Y; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Chen W; Department of Pathology, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Li Z; Department of Pathology, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Horbinski C; Department of Pathology, Mayo Clinic, Jacksonville, FL 32224, USA., Chakravarti A; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Wang QE; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Guo D; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. Electronic address: deliang.guo@osumc.edu.
Source: Cell reports [Cell Rep] 2026 Feb 24; Vol. 45 (2), pp. 116896. Date of Electronic Publication: 2026 Jan 24.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zhong+Y%22">Zhong Y</searchLink>; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Mazik+L%22">Mazik L</searchLink>; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Su+H%22">Su H</searchLink>; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Chiang+CY%22">Chiang CY</searchLink>; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Geng+F%22">Geng F</searchLink>; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Mo+X%22">Mo X</searchLink>; Department of Biomedical Informatics, The Center for Biostatistics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Kou+Y%22">Kou Y</searchLink>; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Pathology, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Pathology, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Horbinski+C%22">Horbinski C</searchLink>; Department of Pathology, Mayo Clinic, Jacksonville, FL 32224, USA.<br /><searchLink fieldCode="AU" term="%22Chakravarti+A%22">Chakravarti A</searchLink>; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Wang+QE%22">Wang QE</searchLink>; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Guo+D%22">Guo D</searchLink>; Department of Radiation Oncology, James Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA. Electronic address: deliang.guo@osumc.edu.
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        Value: 10.1016/j.celrep.2025.116896
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