Dysregulation of the AMPK-SREBP1-FASN axis in MASLD: driving a vicious cycle of lipotoxicity and metabolic-immune crosstalk.

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Title: Dysregulation of the AMPK-SREBP1-FASN axis in MASLD: driving a vicious cycle of lipotoxicity and metabolic-immune crosstalk.
Authors: Zhao Q; GAP Center, Department of Pharmaceutical Analysis, School of Basic Medicine, Graduate School, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, 150040, China., Lu S; GAP Center, Department of Pharmaceutical Analysis, School of Basic Medicine, Graduate School, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, 150040, China., Guan Y; GAP Center, Department of Pharmaceutical Analysis, School of Basic Medicine, Graduate School, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, 150040, China., Sun Z; Department of Gastroenterology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, 150040, China., Qiu S; International Advanced Functional Omics Platform, School of Chinese Medicine, Scientific Experiment Center, Hainan Medical University, Xueyuan Road 3, Haikou, 571199, China., Zhang A; GAP Center, Department of Pharmaceutical Analysis, School of Basic Medicine, Graduate School, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, 150040, China. aihuatcm@163.com.; International Advanced Functional Omics Platform, School of Chinese Medicine, Scientific Experiment Center, Hainan Medical University, Xueyuan Road 3, Haikou, 571199, China. aihuatcm@163.com.
Source: Lipids in health and disease [Lipids Health Dis] 2026 Jan 26; Vol. 25 (1), pp. 62. Date of Electronic Publication: 2026 Jan 26.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147696 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-511X (Electronic) Linking ISSN: 1476511X NLM ISO Abbreviation: Lipids Health Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dysregulation of the AMPK-SREBP1-FASN axis in MASLD: driving a vicious cycle of lipotoxicity and metabolic-immune crosstalk.
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  Data: <searchLink fieldCode="AU" term="%22Zhao+Q%22">Zhao Q</searchLink>; GAP Center, Department of Pharmaceutical Analysis, School of Basic Medicine, Graduate School, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, 150040, China.<br /><searchLink fieldCode="AU" term="%22Lu+S%22">Lu S</searchLink>; GAP Center, Department of Pharmaceutical Analysis, School of Basic Medicine, Graduate School, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, 150040, China.<br /><searchLink fieldCode="AU" term="%22Guan+Y%22">Guan Y</searchLink>; GAP Center, Department of Pharmaceutical Analysis, School of Basic Medicine, Graduate School, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, 150040, China.<br /><searchLink fieldCode="AU" term="%22Sun+Z%22">Sun Z</searchLink>; Department of Gastroenterology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, 150040, China.<br /><searchLink fieldCode="AU" term="%22Qiu+S%22">Qiu S</searchLink>; International Advanced Functional Omics Platform, School of Chinese Medicine, Scientific Experiment Center, Hainan Medical University, Xueyuan Road 3, Haikou, 571199, China.<br /><searchLink fieldCode="AU" term="%22Zhang+A%22">Zhang A</searchLink>; GAP Center, Department of Pharmaceutical Analysis, School of Basic Medicine, Graduate School, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin, 150040, China. aihuatcm@163.com.; International Advanced Functional Omics Platform, School of Chinese Medicine, Scientific Experiment Center, Hainan Medical University, Xueyuan Road 3, Haikou, 571199, China. aihuatcm@163.com.
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  Data: <searchLink fieldCode="JN" term="%22101147696%22">Lipids in health and disease</searchLink> [Lipids Health Dis] 2026 Jan 26; Vol. 25 (1), pp. 62. <i>Date of Electronic Publication: </i>2026 Jan 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101147696 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-511X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221476511X%22">1476511X </searchLink><i>NLM ISO Abbreviation: </i>Lipids Health Dis <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1186/s12944-026-02867-9
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      – Code: eng
        Text: English
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        StartPage: 62
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      – TitleFull: Dysregulation of the AMPK-SREBP1-FASN axis in MASLD: driving a vicious cycle of lipotoxicity and metabolic-immune crosstalk.
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            NameFull: Zhao Q
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            NameFull: Lu S
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              Text: 2026 Jan 26
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              Y: 2026
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