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Interactive Pathways of Key Prognostic Factors in Severe Asthma: A Bayesian Network Comparison of Clinical Trials and Real-World Data.

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Title: Interactive Pathways of Key Prognostic Factors in Severe Asthma: A Bayesian Network Comparison of Clinical Trials and Real-World Data.
Authors: Yadav CP; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Lim LHM; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Price D; Optimum Patient Care Global, Cambridge, England; Observational and Pragmatic Research Institute, Singapore, Singapore; Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland., Roy R; Centre for Quantitative Medicine, Duke NUS Medical School, Singapore., Juang YR; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Beasley R; Medical Research Institute of New Zealand, Wellington, New Zealand., Janson C; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Koh MS; Duke-NUS Medical School, Singapore General Hospital, Singapore; Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore., Wang E; Division of Allergy & Clinical Immunology, Department of Medicine, National Jewish Health, Denver, CO, England; Division of Allergy & Clinical Immunology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, England., Wechsler ME; NJH Cohen Family Asthma Institute, Department of Medicine, National Jewish Health, Denver, CO, England., Jackson DJ; Guy's and St Thomas' NHS Trust, London, England; School of Immunology & Microbial Sciences, King's College London, London, England., Busby J; Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland., Heaney LG; Wellcome-Wolfson Centre for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland., Pfeffer PE; Department of Respiratory Medicine, Barts Health NHS Trust, London, England; Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, England., Mahboub B; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates., Perng DW; Division of Clinical Respiratory, Physiology Chest Department, Taipei Veterans General Hospital, Taipei City, Taiwan; COPD Assembly of the Asian Pacific Society of Respirology, Tokyo, Japan., Cosio BG; Son Espases University Hospital-IdISBa-Ciberes, Mallorca, Spain., Perez-de-Llano L; Pneumology Service, Lucus Augusti University Hospital, EOXI Lugo, Monforte, Cervo, Spain., Al-Lehebi R; Department of Pulmonology, King Fahad Medical City, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Larenas-Linnemann D; Centro de Excelencia en Asma y Alergia, Hospital Médica Sur, Ciudad de México, Mexico., Al-Ahmad M; Microbiology Department, College of Medicine, Kuwait University, Al-Rashed Allergy Center, Ministry of Health, Kuwait City, Kuwait., Rhee CK; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea., Iwanaga T; Sleep Medicine Centre, Kindai University Hospital, Osakasayama, Japan., Heffler E; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Canonica GW; Clinical Research Centre, Smurfit Building Beaumont Hospital, Department of Respiratory Medicine, RCSI, Dublin, Ireland; Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, England., Costello R; Clinical Research Centre, Smurfit Building Beaumont Hospital, Department of Respiratory Medicine, RCSI, Dublin, Ireland., Papadopoulos NG; Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, England; Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece., Papaioannou AI; 2nd Respiratory Medicine Department, National and Kapodistrian, University of Athens Medical School, Attikon University Hospital, Athens, Greece., Porsbjerg CM; Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark., Torres-Duque CA; CINEUMO, Respiratory Research Center, Fundación Neumológica Colombiana, Bogotá, Colombia., Christoff GC; Bulagarian Alliance for Clinical and Translational Allergy, Sofia, Bulgaria., Popov TA; University Hospital 'Sv. Ivan Rilski', Sofia, Bulgaria., Hew M; Allergy, Asthma & Clinical Immunology Service, Alfred Health, Melbourne, VIC, Australia; Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Peters M; Department of Thoracic Medicine, Concord Hospital, Sydney, NSW, Australia., Gibson PG; Australian Severe Asthma Network, Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, NSW, Australia; Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, NSW, Australia., Maspero J; Clinical Research for Allergy and Respiratory Medicine, Buenos Aires, Argentina; CIDEA Foundationthe University Career of Specialists in Allergy and Clinical Immunology, Buenos Aires University School of Medicine, Buenos Aires, Argentina., Bergeron C; Centre for Lung Health, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada., Cerda S; Medical Specialties Unit, Secretary of National Defense, Mexico City, Mexico., Contreras EA; Mexican Council of Clinical Immunology and Allergy, Mexico City Office, Mexico City, Mexico; Department of Allergy and Clinical Immunology, Lic. Adolfo López Mateos Regional Hospital of the Institute of Security and Social Services for State Workers (ISSSTE), Mexico City, Mexico., Chen W; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. Electronic address: wenjiach@nus.edu.sg.
Source: Chest [Chest] 2026 May; Vol. 169 (5), pp. 1183-1197. Date of Electronic Publication: 2026 Jan 24.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0231335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-3543 (Electronic) Linking ISSN: 00123692 NLM ISO Abbreviation: Chest Subsets: MEDLINE
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