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Brain aging in bipolar disorder using a neuroimaging and machine learning-derived metric: Findings from the ENIGMA BD Working Group.

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Title: Brain aging in bipolar disorder using a neuroimaging and machine learning-derived metric: Findings from the ENIGMA BD Working Group.
Authors: Ng HX; Department of Cognitive Science, University of California San Diego, USA., Abé C; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden; Quantify Research, Stockholm, Sweden., Alda M; Department of Psychiatry, Dalhousie University, Canada., Alonso-Lana S; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain., Anmella G; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; Bipolar and Depressive Disorders Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain; University of Barcelona, Spain., Bauer J; University of Münster, Department of Clinical Radiology, Germany., Borgers T; University of Münster, Institute for Translational Psychiatry, Germany., Brosch K; Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA., Busatto GF; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil., Bøen E; Psychosomatic and CL Psychiatry, Clinic for Mental Health and Addiction, Oslo University Hospital, Norway., Canales-Rodríguez EJ; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; Department of Signal Theory, Networking and Communications & Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI), University of Granada, Spain., Cannon DM; Clinical Neuroimaging Laboratory, Center for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland., Chaim-Avancini TM; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil., Cole JH; Centre for Medical Image Computing, Department of Computer Science, University College London, United Kingdom of Great Britain and Northern Ireland; Dementia Research Centre, Queen Square Institute of Neurology, University College London, United Kingdom of Great Britain and Northern Ireland., Dannlowski U; University of Münster, Institute for Translational Psychiatry, Germany; Department of Psychiatry, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Bielefeld University., De La Cruz A; Department of Psychology, San Diego State University, USA., Einenkel K; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Germany., Elvsåshagen T; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Norway; Department of Neurology, Oslo University Hospital, Norway; Department of Behavioural Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway., Favre P; CEA, UNIACT, Psychiatry Team, Neurospin, France; APHP, Mondor University Hospitals, INSERM U955 Translational Psychiatry Team, IMRB, France., Fisch L; University of Münster, Institute for Translational Psychiatry, Germany., Flinkenflügel K; University of Münster, Institute for Translational Psychiatry, Germany., Foley S; CUBRIC, Cardiff University, United Kingdom of Great Britain and Northern Ireland., Fullerton JM; Neuroscience Research Australia, Sydney, NSW, Australia; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Goltermann J; University of Münster, Institute for Translational Psychiatry, Germany., Grotegerd D; University of Münster, Institute for Translational Psychiatry, Germany., Gruber O; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Germany., Haarman BCM; Department of Psychiatry, University Medical Center Groningen, University of Groningen, the Netherlands., Hahn T; University of Münster, Institute for Translational Psychiatry, Germany., Hajek T; Department of Psychiatry, Dalhousie University, Canada; National Institute of Mental Health Klecany, Czechia., Han LKM; Department of Psychiatry, Amsterdam University Medical Centers, Vrije Universiteit and GGZ inGeest, Amsterdam Neuroscience, Amsterdam, the Netherlands; Orygen, Parkville, VIC, Australia; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia., Henry C; Université de Paris, Service Hospitalo-Universitaire, GHU Paris Psychiatrie & Neuroscience, France., Hidalgo-Mazzei D; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; Bipolar and Depressive Disorders Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain; University of Barcelona, Spain., Houenou J; CEA, UNIACT, Psychiatry Team, Neurospin, France; APHP, Mondor University Hospitals, INSERM U955 Translational Psychiatry Team, IMRB, France; Department of Psychiatry, The University of Melbourne and Mental Services, Northern Health, Melbourne, Australia., Howells FM; Neuroscience Institute, University of Cape Town, South Africa; Department of Psychiatry and Mental Health, University of Cape Town, South Africa., Ingvar M; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Jiménez E; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; Bipolar and Depressive Disorders Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain; University of Barcelona, Spain., Karuk A; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain., Kircher T; Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg, Germany., Klahn L; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden., Kraus A; University of Münster, Institute for Translational Psychiatry, Germany., Krug A; Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany., Krämer B; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Germany., Kuplicki RT; Laureate Institute for Brain Research, USA., Lafer B; Department of Psychiatry, University of São Paulo Medical School, Brazil., Landén M; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Machado-Vieira R; UTHealth Bipolar Disorder Program, Department of Psychiatry and Behavioral Sciences, University of Texas, Houston, TX, USA; Department of Psychiatry, University of Sao Paulo, Brazil., Malt UF; Department of Behavioural Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway., Martyn FM; Clinical Neuroimaging Laboratory, Center for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland., McDonald C; Clinical Neuroimaging Laboratory, Center for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland., McPhilemy G; Clinical Neuroimaging Laboratory, Center for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland., Meinert S; University of Münster, Institute for Translational Psychiatry, Germany; University of Münster, Institute for Translational Neuroscience, Germany., Meller T; Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg, Germany., Mitchell PB; Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Mwangi B; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, USA., Nabulsi L; Clinical Neuroimaging Laboratory, Center for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Nenadić I; Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg, Germany., Opel N; University of Münster, Institute for Translational Psychiatry, Germany; Department of Psychiatry, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Jena-Magdeburg-Halle, Germany; German Center for Mental Health (DZPG), Site Jena-Magdeburg-Halle, Germany., Otaduy MCG; LIM44, Departamento e Instituto de Radiologia, Faculdade de Medicina, Universidade de São Paulo, Brazil., Overs BJ; Neuroscience Research Australia, Sydney, NSW, Australia., Polosan M; Univ. Grenoble Alpes ; Inserm U1216, Grenoble Institut de Neurosciences, CHU de Grenoble, F-38000 Grenoble, France., Pomarol-Clotet E; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain., Pouchon A; Univ. Grenoble Alpes ; Inserm U1216, Grenoble Institut de Neurosciences, CHU de Grenoble, F-38000 Grenoble, France., Radua J; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; University of Barcelona, Spain; Early Psychosis: Interventions and Clinical-detection (EPIC) lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom of Great Britain and Northern Ireland., Rauer L; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Germany., Repple J; University of Münster, Institute for Translational Psychiatry, Germany; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt - Goethe University, Frankfurt am Main, Germany., Roberts G; Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Rodríguez-Cano E; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain., Rosa PGP; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil., Salvador R; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain., Sarró S; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain., Satterthwaite TD; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, USA., Savitz J; Laureate Institute for Brain Research, USA; Oxley College of Health Sciences, The University of Tulsa, USA., Schmaal L; Orygen, Parkville, VIC, Australia; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia., Schofield PR; Neuroscience Research Australia, Sydney, NSW, Australia; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Serpa M; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil., Sim K; West Region, Institute of Mental Health, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Soares JC; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, USA., Topolski N; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, USA., Soeiro-de-Souza MG; Department of Psychiatry, University of São Paulo Medical School, Brazil., Stein DJ; Neuroscience Institute, University of Cape Town, South Africa; Department of Psychiatry and Mental Health, University of Cape Town, South Africa; SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, South Africa., Stein F; Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg, Germany., Sutherland AN; Department of Psychiatry, University of California San Diego, USA., Temmingh HS; Department of Psychiatry and Mental Health, University of Cape Town, South Africa; Therapeutic and Intermediate Service, Valkenberg Hospital, South Africa., Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Uhlmann A; Department of Psychiatry and Mental Health, University of Cape Town, South Africa; Department of Child and Adolescent Psychiatry and Psychotherapy, TU Dresden, Germany., Vieta E; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; Bipolar and Depressive Disorders Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain; University of Barcelona, Spain., Vilajosana E; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; University of Barcelona, Spain., Wolf DH; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, USA., Wu MJ; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, USA., Zunta-Soares GB; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, USA., Zanetti MV; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil; Hospital Sírio-Libanês, São Paulo, Brazil., van den Brink W; Department of Psychiatry, Amsterdam University Medical Centers, the Netherlands., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Andreassen OA; NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Norway., Ching CRK; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Eyler LT; Department of Psychiatry, University of California San Diego, USA; Desert-Pacific Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, USA. Electronic address: lteyler@health.ucsd.edu.
Corporate Authors: ENIGMA Bipolar Disorder Working Group, ENIGMA Brain Age Working Group
Source: Journal of affective disorders [J Affect Disord] 2026 Jun 15; Vol. 403, pp. 121234. Date of Electronic Publication: 2026 Jan 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Brain aging in bipolar disorder using a neuroimaging and machine learning-derived metric: Findings from the ENIGMA BD Working Group.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Ng+HX%22">Ng HX</searchLink>; Department of Cognitive Science, University of California San Diego, USA.<br /><searchLink fieldCode="AU" term="%22Abé+C%22">Abé C</searchLink>; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden; Quantify Research, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Alda+M%22">Alda M</searchLink>; Department of Psychiatry, Dalhousie University, Canada.<br /><searchLink fieldCode="AU" term="%22Alonso-Lana+S%22">Alonso-Lana S</searchLink>; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Anmella+G%22">Anmella G</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; Bipolar and Depressive Disorders Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain; University of Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bauer+J%22">Bauer J</searchLink>; University of Münster, Department of Clinical Radiology, Germany.<br /><searchLink fieldCode="AU" term="%22Borgers+T%22">Borgers T</searchLink>; University of Münster, Institute for Translational Psychiatry, Germany.<br /><searchLink fieldCode="AU" term="%22Brosch+K%22">Brosch K</searchLink>; Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA.<br /><searchLink fieldCode="AU" term="%22Busatto+GF%22">Busatto GF</searchLink>; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Bøen+E%22">Bøen E</searchLink>; Psychosomatic and CL Psychiatry, Clinic for Mental Health and Addiction, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Canales-Rodríguez+EJ%22">Canales-Rodríguez EJ</searchLink>; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; Department of Signal Theory, Networking and Communications & Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI), University of Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Cannon+DM%22">Cannon DM</searchLink>; Clinical Neuroimaging Laboratory, Center for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Chaim-Avancini+TM%22">Chaim-Avancini TM</searchLink>; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Cole+JH%22">Cole JH</searchLink>; Centre for Medical Image Computing, Department of Computer Science, University College London, United Kingdom of Great Britain and Northern Ireland; Dementia Research Centre, Queen Square Institute of Neurology, University College London, United Kingdom of Great Britain and Northern Ireland.<br /><searchLink fieldCode="AU" term="%22Dannlowski+U%22">Dannlowski U</searchLink>; University of Münster, Institute for Translational Psychiatry, Germany; Department of Psychiatry, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Bielefeld University.<br /><searchLink fieldCode="AU" term="%22De+La+Cruz+A%22">De La Cruz A</searchLink>; Department of Psychology, San Diego State University, USA.<br /><searchLink fieldCode="AU" term="%22Einenkel+K%22">Einenkel K</searchLink>; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Germany.<br /><searchLink fieldCode="AU" term="%22Elvsåshagen+T%22">Elvsåshagen T</searchLink>; Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital, Norway; Department of Neurology, Oslo University Hospital, Norway; Department of Behavioural Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Favre+P%22">Favre P</searchLink>; CEA, UNIACT, Psychiatry Team, Neurospin, France; APHP, Mondor University Hospitals, INSERM U955 Translational Psychiatry Team, IMRB, France.<br /><searchLink fieldCode="AU" term="%22Fisch+L%22">Fisch L</searchLink>; University of Münster, Institute for Translational Psychiatry, Germany.<br /><searchLink fieldCode="AU" term="%22Flinkenflügel+K%22">Flinkenflügel K</searchLink>; University of Münster, Institute for Translational Psychiatry, Germany.<br /><searchLink fieldCode="AU" term="%22Foley+S%22">Foley S</searchLink>; CUBRIC, Cardiff University, United Kingdom of Great Britain and Northern Ireland.<br /><searchLink fieldCode="AU" term="%22Fullerton+JM%22">Fullerton JM</searchLink>; Neuroscience Research Australia, Sydney, NSW, Australia; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Goltermann+J%22">Goltermann J</searchLink>; University of Münster, Institute for Translational Psychiatry, Germany.<br /><searchLink fieldCode="AU" term="%22Grotegerd+D%22">Grotegerd D</searchLink>; University of Münster, Institute for Translational Psychiatry, Germany.<br /><searchLink fieldCode="AU" term="%22Gruber+O%22">Gruber O</searchLink>; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Germany.<br /><searchLink fieldCode="AU" term="%22Haarman+BCM%22">Haarman BCM</searchLink>; Department of Psychiatry, University Medical Center Groningen, University of Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hahn+T%22">Hahn T</searchLink>; University of Münster, Institute for Translational Psychiatry, Germany.<br /><searchLink fieldCode="AU" term="%22Hajek+T%22">Hajek T</searchLink>; Department of Psychiatry, Dalhousie University, Canada; National Institute of Mental Health Klecany, Czechia.<br /><searchLink fieldCode="AU" term="%22Han+LKM%22">Han LKM</searchLink>; Department of Psychiatry, Amsterdam University Medical Centers, Vrije Universiteit and GGZ inGeest, Amsterdam Neuroscience, Amsterdam, the Netherlands; Orygen, Parkville, VIC, Australia; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Henry+C%22">Henry C</searchLink>; Université de Paris, Service Hospitalo-Universitaire, GHU Paris Psychiatrie & Neuroscience, France.<br /><searchLink fieldCode="AU" term="%22Hidalgo-Mazzei+D%22">Hidalgo-Mazzei D</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; Bipolar and Depressive Disorders Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain; University of Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Houenou+J%22">Houenou J</searchLink>; CEA, UNIACT, Psychiatry Team, Neurospin, France; APHP, Mondor University Hospitals, INSERM U955 Translational Psychiatry Team, IMRB, France; Department of Psychiatry, The University of Melbourne and Mental Services, Northern Health, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Howells+FM%22">Howells FM</searchLink>; Neuroscience Institute, University of Cape Town, South Africa; Department of Psychiatry and Mental Health, University of Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Ingvar+M%22">Ingvar M</searchLink>; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden.<br /><searchLink fieldCode="AU" term="%22Jahanshad+N%22">Jahanshad N</searchLink>; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jiménez+E%22">Jiménez E</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; Bipolar and Depressive Disorders Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain; University of Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Karuk+A%22">Karuk A</searchLink>; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Kircher+T%22">Kircher T</searchLink>; Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Klahn+L%22">Klahn L</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Kraus+A%22">Kraus A</searchLink>; University of Münster, Institute for Translational Psychiatry, Germany.<br /><searchLink fieldCode="AU" term="%22Krug+A%22">Krug A</searchLink>; Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Krämer+B%22">Krämer B</searchLink>; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Germany.<br /><searchLink fieldCode="AU" term="%22Kuplicki+RT%22">Kuplicki RT</searchLink>; Laureate Institute for Brain Research, USA.<br /><searchLink fieldCode="AU" term="%22Lafer+B%22">Lafer B</searchLink>; Department of Psychiatry, University of São Paulo Medical School, Brazil.<br /><searchLink fieldCode="AU" term="%22Landén+M%22">Landén M</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Machado-Vieira+R%22">Machado-Vieira R</searchLink>; UTHealth Bipolar Disorder Program, Department of Psychiatry and Behavioral Sciences, University of Texas, Houston, TX, USA; Department of Psychiatry, University of Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Malt+UF%22">Malt UF</searchLink>; Department of Behavioural Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Martyn+FM%22">Martyn FM</searchLink>; Clinical Neuroimaging Laboratory, Center for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22McDonald+C%22">McDonald C</searchLink>; Clinical Neuroimaging Laboratory, Center for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22McPhilemy+G%22">McPhilemy G</searchLink>; Clinical Neuroimaging Laboratory, Center for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Meinert+S%22">Meinert S</searchLink>; University of Münster, Institute for Translational Psychiatry, Germany; University of Münster, Institute for Translational Neuroscience, Germany.<br /><searchLink fieldCode="AU" term="%22Meller+T%22">Meller T</searchLink>; Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mitchell+PB%22">Mitchell PB</searchLink>; Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Mwangi+B%22">Mwangi B</searchLink>; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, USA.<br /><searchLink fieldCode="AU" term="%22Nabulsi+L%22">Nabulsi L</searchLink>; Clinical Neuroimaging Laboratory, Center for Neuroimaging, Cognition & Genomics (NICOG), Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nenadić+I%22">Nenadić I</searchLink>; Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Opel+N%22">Opel N</searchLink>; University of Münster, Institute for Translational Psychiatry, Germany; Department of Psychiatry, Jena University Hospital/Friedrich-Schiller-University Jena, Jena, Germany; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Jena-Magdeburg-Halle, Germany; German Center for Mental Health (DZPG), Site Jena-Magdeburg-Halle, Germany.<br /><searchLink fieldCode="AU" term="%22Otaduy+MCG%22">Otaduy MCG</searchLink>; LIM44, Departamento e Instituto de Radiologia, Faculdade de Medicina, Universidade de São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Overs+BJ%22">Overs BJ</searchLink>; Neuroscience Research Australia, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Polosan+M%22">Polosan M</searchLink>; Univ. Grenoble Alpes ; Inserm U1216, Grenoble Institut de Neurosciences, CHU de Grenoble, F-38000 Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Pomarol-Clotet+E%22">Pomarol-Clotet E</searchLink>; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pouchon+A%22">Pouchon A</searchLink>; Univ. Grenoble Alpes ; Inserm U1216, Grenoble Institut de Neurosciences, CHU de Grenoble, F-38000 Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Radua+J%22">Radua J</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; University of Barcelona, Spain; Early Psychosis: Interventions and Clinical-detection (EPIC) lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom of Great Britain and Northern Ireland.<br /><searchLink fieldCode="AU" term="%22Rauer+L%22">Rauer L</searchLink>; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Germany.<br /><searchLink fieldCode="AU" term="%22Repple+J%22">Repple J</searchLink>; University of Münster, Institute for Translational Psychiatry, Germany; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt - Goethe University, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Roberts+G%22">Roberts G</searchLink>; Discipline of Psychiatry & Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Cano+E%22">Rodríguez-Cano E</searchLink>; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rosa+PGP%22">Rosa PGP</searchLink>; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Salvador+R%22">Salvador R</searchLink>; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sarró+S%22">Sarró S</searchLink>; FIDMAG Germanes Hospitalàries Research Foundation, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Satterthwaite+TD%22">Satterthwaite TD</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, USA.<br /><searchLink fieldCode="AU" term="%22Savitz+J%22">Savitz J</searchLink>; Laureate Institute for Brain Research, USA; Oxley College of Health Sciences, The University of Tulsa, USA.<br /><searchLink fieldCode="AU" term="%22Schmaal+L%22">Schmaal L</searchLink>; Orygen, Parkville, VIC, Australia; Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Schofield+PR%22">Schofield PR</searchLink>; Neuroscience Research Australia, Sydney, NSW, Australia; School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Serpa+M%22">Serpa M</searchLink>; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Sim+K%22">Sim K</searchLink>; West Region, Institute of Mental Health, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Soares+JC%22">Soares JC</searchLink>; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, USA.<br /><searchLink fieldCode="AU" term="%22Topolski+N%22">Topolski N</searchLink>; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, USA.<br /><searchLink fieldCode="AU" term="%22Soeiro-de-Souza+MG%22">Soeiro-de-Souza MG</searchLink>; Department of Psychiatry, University of São Paulo Medical School, Brazil.<br /><searchLink fieldCode="AU" term="%22Stein+DJ%22">Stein DJ</searchLink>; Neuroscience Institute, University of Cape Town, South Africa; Department of Psychiatry and Mental Health, University of Cape Town, South Africa; SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Stein+F%22">Stein F</searchLink>; Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sutherland+AN%22">Sutherland AN</searchLink>; Department of Psychiatry, University of California San Diego, USA.<br /><searchLink fieldCode="AU" term="%22Temmingh+HS%22">Temmingh HS</searchLink>; Department of Psychiatry and Mental Health, University of Cape Town, South Africa; Therapeutic and Intermediate Service, Valkenberg Hospital, South Africa.<br /><searchLink fieldCode="AU" term="%22Thomopoulos+SI%22">Thomopoulos SI</searchLink>; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.<br /><searchLink fieldCode="AU" term="%22Uhlmann+A%22">Uhlmann A</searchLink>; Department of Psychiatry and Mental Health, University of Cape Town, South Africa; Department of Child and Adolescent Psychiatry and Psychotherapy, TU Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Vieta+E%22">Vieta E</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; Bipolar and Depressive Disorders Unit, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain; University of Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Vilajosana+E%22">Vilajosana E</searchLink>; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain; University of Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Wolf+DH%22">Wolf DH</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, USA.<br /><searchLink fieldCode="AU" term="%22Wu+MJ%22">Wu MJ</searchLink>; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, USA.<br /><searchLink fieldCode="AU" term="%22Zunta-Soares+GB%22">Zunta-Soares GB</searchLink>; Center Of Excellence On Mood Disorders, Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, USA.<br /><searchLink fieldCode="AU" term="%22Zanetti+MV%22">Zanetti MV</searchLink>; Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil; Hospital Sírio-Libanês, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22van+den+Brink+W%22">van den Brink W</searchLink>; Department of Psychiatry, Amsterdam University Medical Centers, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Thompson+PM%22">Thompson PM</searchLink>; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.<br /><searchLink fieldCode="AU" term="%22Andreassen+OA%22">Andreassen OA</searchLink>; NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Ching+CRK%22">Ching CRK</searchLink>; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.<br /><searchLink fieldCode="AU" term="%22Eyler+LT%22">Eyler LT</searchLink>; Department of Psychiatry, University of California San Diego, USA; Desert-Pacific Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, USA. Electronic address: lteyler@health.ucsd.edu.
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  Data: <searchLink fieldCode="CA" term="%22ENIGMA+Bipolar+Disorder+Working+Group%22">ENIGMA Bipolar Disorder Working Group</searchLink><br /><searchLink fieldCode="CA" term="%22ENIGMA+Brain+Age+Working+Group%22">ENIGMA Brain Age Working Group</searchLink>
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  Data: <searchLink fieldCode="JN" term="%227906073%22">Journal of affective disorders</searchLink> [J Affect Disord] 2026 Jun 15; Vol. 403, pp. 121234. <i>Date of Electronic Publication: </i>2026 Jan 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2FNorth-Holland+Biomedical+Press%22">Elsevier/North-Holland Biomedical Press </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>7906073 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-2517 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201650327%22">01650327 </searchLink><i>NLM ISO Abbreviation: </i>J Affect Disord <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jad.2026.121234
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      – TitleFull: Brain aging in bipolar disorder using a neuroimaging and machine learning-derived metric: Findings from the ENIGMA BD Working Group.
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      – PersonEntity:
          Name:
            NameFull: Sutherland AN
      – PersonEntity:
          Name:
            NameFull: Temmingh HS
      – PersonEntity:
          Name:
            NameFull: Thomopoulos SI
      – PersonEntity:
          Name:
            NameFull: Uhlmann A
      – PersonEntity:
          Name:
            NameFull: Vieta E
      – PersonEntity:
          Name:
            NameFull: Vilajosana E
      – PersonEntity:
          Name:
            NameFull: Wolf DH
      – PersonEntity:
          Name:
            NameFull: Wu MJ
      – PersonEntity:
          Name:
            NameFull: Zunta-Soares GB
      – PersonEntity:
          Name:
            NameFull: Zanetti MV
      – PersonEntity:
          Name:
            NameFull: van den Brink W
      – PersonEntity:
          Name:
            NameFull: Thompson PM
      – PersonEntity:
          Name:
            NameFull: Andreassen OA
      – PersonEntity:
          Name:
            NameFull: Ching CRK
      – PersonEntity:
          Name:
            NameFull: Eyler LT
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 06
              Text: 2026 Jun 15
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1573-2517
          Numbering:
            – Type: volume
              Value: 403
          Titles:
            – TitleFull: Journal of affective disorders
              Type: main
ResultId 1