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Reprogramming the melanoma tumor immune microenvironment via combinatorial signal 2/3 gene delivery.

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Title: Reprogramming the melanoma tumor immune microenvironment via combinatorial signal 2/3 gene delivery.
Authors: Luly KM; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Zhou XMM; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Surwase SS; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Rocher EE; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Kollings J; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Lu C; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Will E; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Zhu Q; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Anders RA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Green JJ; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, Maryland, USA.; Departments of Neurosurgery and Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Departments of Materials Science & Engineering and Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Tzeng SY; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Sunshine JC; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA joelsunshine@jhmi.edu.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2026 Jan 27; Vol. 14 (1). Date of Electronic Publication: 2026 Jan 27.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
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  Data: Reprogramming the melanoma tumor immune microenvironment via combinatorial signal 2/3 gene delivery.
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  Data: <searchLink fieldCode="AU" term="%22Luly+KM%22">Luly KM</searchLink>; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+XMM%22">Zhou XMM</searchLink>; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Surwase+SS%22">Surwase SS</searchLink>; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Rocher+EE%22">Rocher EE</searchLink>; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Kollings+J%22">Kollings J</searchLink>; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Lu+C%22">Lu C</searchLink>; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Will+E%22">Will E</searchLink>; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+Q%22">Zhu Q</searchLink>; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Anders+RA%22">Anders RA</searchLink>; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Green+JJ%22">Green JJ</searchLink>; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, Maryland, USA.; Departments of Neurosurgery and Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Departments of Materials Science & Engineering and Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Tzeng+SY%22">Tzeng SY</searchLink>; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Sunshine+JC%22">Sunshine JC</searchLink>; Center for Translational ImmunoEngineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA joelsunshine@jhmi.edu.; Translational Therapeutics & Regenerative Engineering Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2026 Jan 27; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Jan 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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        Value: 10.1136/jitc-2025-012856
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        Text: English
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      – TitleFull: Reprogramming the melanoma tumor immune microenvironment via combinatorial signal 2/3 gene delivery.
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              Text: 2026 Jan 27
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