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Early functional changes and plasma GFAP in Swedish families with Autosomal Dominant Alzheimer's disease mutations.

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Title: Early functional changes and plasma GFAP in Swedish families with Autosomal Dominant Alzheimer's disease mutations.
Authors: Luckett ES; Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Blickagången 16, SE-14183, Huddinge, Sweden., Zapater-Fajari M; Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Blickagången 16, SE-14183, Huddinge, Sweden., Almkvist O; Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Blickagången 16, SE-14183, Huddinge, Sweden.; Theme Inflammation and Aging, Karolinska University Hospital, Hälsovägen, SE-14186, Stockholm, Sweden., Johansson C; Theme Inflammation and Aging, Karolinska University Hospital, Hälsovägen, SE-14186, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Visionsgatan 4, SE-17164, Stockholm, Sweden., Chiotis K; Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Blickagången 16, SE-14183, Huddinge, Sweden.; Theme Inflammation and Aging, Karolinska University Hospital, Hälsovägen, SE-14186, Stockholm, Sweden., Bucci M; Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Blickagången 16, SE-14183, Huddinge, Sweden.; Turku PET Centre, University of Turku, Turku University Hospital and Åbo Akademi University, 20251, Turku, Finland., Wall A; Department of Surgical Sciences, Section of Molecular Imaging & Medical physics, Uppsala University, 75185, Uppsala, Sweden.; PET Centre, Uppsala University Hospital, 75185, Uppsala, Sweden., Ashton NJ; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE- Wallinsgatan 6, 43141, Mölndal, Sweden.; Institute of Psychiatry, Psychology & Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Rd, London, SE5 9RX, UK.; NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia at South London & Maudsley NHS Foundation, 16 De Crespigny Park, London, SE5 8AF, UK., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE- Wallinsgatan 6, 43141, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Klin Neurokemi Lab Hus V3, SE-43180, Mölndal, Sweden., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE- Wallinsgatan 6, 43141, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Klin Neurokemi Lab Hus V3, SE-43180, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Units 1501-1502, 1512-1518, 15/F Building 17W, 17 Science Park W Ave, Science Park, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave J5/1 Mezzanine, Madison, WI, 53792, USA.; Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 53792-2420, Madison, WI, USA.; Centre for Brain Research, Indian Institute of Science, C.V. Raman Avenue, Bangalore, 560 012, India., Rodriguez-Vieitez E; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Visionsgatan 4, SE-17164, Stockholm, Sweden., Graff C; Theme Inflammation and Aging, Karolinska University Hospital, Hälsovägen, SE-14186, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Visionsgatan 4, SE-17164, Stockholm, Sweden.; Unit for Hereditary Dementia, Karolinska University Hospital-Solna, Karolinska Vägen 22, SE-171 64, Solna, Sweden., Nordberg A; Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Blickagången 16, SE-14183, Huddinge, Sweden. agneta.k.nordberg@ki.se.; Theme Inflammation and Aging, Karolinska University Hospital, Hälsovägen, SE-14186, Stockholm, Sweden. agneta.k.nordberg@ki.se.
Source: Translational psychiatry [Transl Psychiatry] 2026 Jan 27; Vol. 16 (1), pp. 67. Date of Electronic Publication: 2026 Jan 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
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  Data: Early functional changes and plasma GFAP in Swedish families with Autosomal Dominant Alzheimer's disease mutations.
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  Data: <searchLink fieldCode="AU" term="%22Luckett+ES%22">Luckett ES</searchLink>; Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Blickagången 16, SE-14183, Huddinge, Sweden.<br /><searchLink fieldCode="AU" term="%22Zapater-Fajari+M%22">Zapater-Fajari M</searchLink>; Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Blickagången 16, SE-14183, Huddinge, Sweden.<br /><searchLink fieldCode="AU" term="%22Almkvist+O%22">Almkvist O</searchLink>; Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Blickagången 16, SE-14183, Huddinge, Sweden.; Theme Inflammation and Aging, Karolinska University Hospital, Hälsovägen, SE-14186, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Johansson+C%22">Johansson C</searchLink>; Theme Inflammation and Aging, Karolinska University Hospital, Hälsovägen, SE-14186, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Visionsgatan 4, SE-17164, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Chiotis+K%22">Chiotis K</searchLink>; Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Blickagången 16, SE-14183, Huddinge, Sweden.; Theme Inflammation and Aging, Karolinska University Hospital, Hälsovägen, SE-14186, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bucci+M%22">Bucci M</searchLink>; Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Blickagången 16, SE-14183, Huddinge, Sweden.; Turku PET Centre, University of Turku, Turku University Hospital and Åbo Akademi University, 20251, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Wall+A%22">Wall A</searchLink>; Department of Surgical Sciences, Section of Molecular Imaging & Medical physics, Uppsala University, 75185, Uppsala, Sweden.; PET Centre, Uppsala University Hospital, 75185, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Ashton+NJ%22">Ashton NJ</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE- Wallinsgatan 6, 43141, Mölndal, Sweden.; Institute of Psychiatry, Psychology & Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Rd, London, SE5 9RX, UK.; NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia at South London & Maudsley NHS Foundation, 16 De Crespigny Park, London, SE5 8AF, UK.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE- Wallinsgatan 6, 43141, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Klin Neurokemi Lab Hus V3, SE-43180, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE- Wallinsgatan 6, 43141, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Klin Neurokemi Lab Hus V3, SE-43180, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Units 1501-1502, 1512-1518, 15/F Building 17W, 17 Science Park W Ave, Science Park, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave J5/1 Mezzanine, Madison, WI, 53792, USA.; Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 53792-2420, Madison, WI, USA.; Centre for Brain Research, Indian Institute of Science, C.V. Raman Avenue, Bangalore, 560 012, India.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Vieitez+E%22">Rodriguez-Vieitez E</searchLink>; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Visionsgatan 4, SE-17164, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Graff+C%22">Graff C</searchLink>; Theme Inflammation and Aging, Karolinska University Hospital, Hälsovägen, SE-14186, Stockholm, Sweden.; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Visionsgatan 4, SE-17164, Stockholm, Sweden.; Unit for Hereditary Dementia, Karolinska University Hospital-Solna, Karolinska Vägen 22, SE-171 64, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Nordberg+A%22">Nordberg A</searchLink>; Department of Neurobiology, Care Sciences and Society, Centre for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, Blickagången 16, SE-14183, Huddinge, Sweden. agneta.k.nordberg@ki.se.; Theme Inflammation and Aging, Karolinska University Hospital, Hälsovägen, SE-14186, Stockholm, Sweden. agneta.k.nordberg@ki.se.
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