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A phase 2, open label, clinical trial of pre-surgical and adjuvant treatment of recurrent glioblastoma with tremelimumab and durvalumab alone and in combination.

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Title: A phase 2, open label, clinical trial of pre-surgical and adjuvant treatment of recurrent glioblastoma with tremelimumab and durvalumab alone and in combination.
Authors: Dixit KS; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA. karan.dixit@northwestern.edu.; Department of Neurology, Northwestern University, Chicago, IL, USA. karan.dixit@northwestern.edu., Kumthekar P; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Neurology, Northwestern University, Chicago, IL, USA., Lukas RV; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Neurology, Northwestern University, Chicago, IL, USA., Williams A; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Neurology, Northwestern University, Chicago, IL, USA., Tate MC; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Neurosurgery, Northwestern University, Chicago, IL, USA., Chandler JP; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Neurosurgery, Northwestern University, Chicago, IL, USA., Jamshidi P; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Pathology, Northwestern University, Chicago, IL, USA., Helenowski I; Biostatistics Collaborative Core, Loyola University, Chicago, IL, USA., Zhang H; Department of Preventive Medicine, Northwestern University, Chicago, IL, USA., Bloch O; Department of Neurosurgery, University of California, Davis, Sacramento, CA, USA., Raizer JJ; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Neurology, Northwestern University, Chicago, IL, USA.
Source: Journal of neuro-oncology [J Neurooncol] 2026 Jan 28; Vol. 176 (3), pp. 185. Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A phase 2, open label, clinical trial of pre-surgical and adjuvant treatment of recurrent glioblastoma with tremelimumab and durvalumab alone and in combination.
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  Data: <searchLink fieldCode="AU" term="%22Dixit+KS%22">Dixit KS</searchLink>; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA. karan.dixit@northwestern.edu.; Department of Neurology, Northwestern University, Chicago, IL, USA. karan.dixit@northwestern.edu.<br /><searchLink fieldCode="AU" term="%22Kumthekar+P%22">Kumthekar P</searchLink>; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Neurology, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Lukas+RV%22">Lukas RV</searchLink>; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Neurology, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Williams+A%22">Williams A</searchLink>; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Neurology, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Tate+MC%22">Tate MC</searchLink>; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Neurosurgery, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chandler+JP%22">Chandler JP</searchLink>; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Neurosurgery, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Jamshidi+P%22">Jamshidi P</searchLink>; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Pathology, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Helenowski+I%22">Helenowski I</searchLink>; Biostatistics Collaborative Core, Loyola University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Preventive Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Bloch+O%22">Bloch O</searchLink>; Department of Neurosurgery, University of California, Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Raizer+JJ%22">Raizer JJ</searchLink>; Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL, USA.; Department of Neurology, Northwestern University, Chicago, IL, USA.
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  Data: <searchLink fieldCode="JN" term="%228309335%22">Journal of neuro-oncology</searchLink> [J Neurooncol] 2026 Jan 28; Vol. 176 (3), pp. 185. <i>Date of Electronic Publication: </i>2026 Jan 28.
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  Data: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8309335 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-7373 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220167594X%22">0167594X </searchLink><i>NLM ISO Abbreviation: </i>J Neurooncol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11060-026-05446-1
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              Text: 2026 Jan 28
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