Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial.
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| Title: | Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial. |
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| Authors: | Duttagupta S; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Department of Microbiology & Immunology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada., Messaoudene M; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Hunter S; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Desilets A; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Hemato-Oncology Division, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Jamal R; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Hemato-Oncology Division, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Mihalcioiu C; Departments of Oncology and Medicine, McGill University, Montreal, Québec, Canada., Belkaid W; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Marcoux N; Hemato-Oncology Division, Centre hospitalier de l'Université de Québec, Québec City, Québec, Canada., Fidelle M; Université Paris-Saclay, U1015 INSERM, Gustave Roussy, Ligue Labellisée contre le Cancer, Villejuif, France., Suissa D; Université Paris-Saclay, U1015 INSERM, Gustave Roussy, Ligue Labellisée contre le Cancer, Villejuif, France., Ponce M; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Geiger M; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Malo J; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Piccinno G; Department of Computational, Cellular and Integrative Biology, University of Trento, Trento, Italy., Punčochář M; Department of Computational, Cellular and Integrative Biology, University of Trento, Trento, Italy., Filin A; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Heidrich V; Department of Computational, Cellular and Integrative Biology, University of Trento, Trento, Italy., Rusu D; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Mbaye B; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Durand S; Centre de Recherche des Cordeliers, Équipe labellisée par la Ligue contre le cancer, Institut Universitaire de France, Paris, France.; Université Paris-Saclay, INSERM US23 / CNRS UAR 3655, Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France., Ben Aissa I; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Puller V; GMT Science, Rouen, France., de Lahondès R; GMT Science, Rouen, France., Blais N; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Hemato-Oncology Division, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Tehfe M; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Hemato-Oncology Division, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Owen S; Departments of Oncology and Medicine, McGill University, Montreal, Québec, Canada., Bélanger K; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Hemato-Oncology Division, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Parvathy SN; Department of Medicine, Division of Infectious Diseases, Western University, London, Ontario, Canada.; Division of Infectious Diseases, St. Joseph's Health Care, London, Ontario, Canada.; Lawson Research Institute, London, Ontario, Canada., Shieh B; Departments of Oncology and Medicine, McGill University, Montreal, Québec, Canada., Raphael J; Verspeeten Family Cancer Centre at London Health Sciences Centre, London, Ontario, Canada.; Department of Oncology, Division of Medical Oncology, Schulich School of Medicine and Dentistry at Western University, London, Ontario, Canada., Lenehan J; Verspeeten Family Cancer Centre at London Health Sciences Centre, London, Ontario, Canada.; Department of Oncology, Division of Medical Oncology, Schulich School of Medicine and Dentistry at Western University, London, Ontario, Canada., Breadner D; Verspeeten Family Cancer Centre at London Health Sciences Centre, London, Ontario, Canada.; Department of Oncology, Division of Medical Oncology, Schulich School of Medicine and Dentistry at Western University, London, Ontario, Canada., Rothenstein J; R.S. McLaughlin Durham Regional Cancer Center at Lakeridge Health, Oshawa, Ontario, Canada., Rozza N; Departments of Oncology and Medicine, McGill University, Montreal, Québec, Canada., Maillou J; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Department of Microbiology & Immunology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada., Nili S; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Prifti DK; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada., Pinto F; Department of Computational, Cellular and Integrative Biology, University of Trento, Trento, Italy., Armanini F; Department of Computational, Cellular and Integrative Biology, University of Trento, Trento, Italy., Kim-Schulze S; Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marron TU; Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kroemer G; Centre de Recherche des Cordeliers, Équipe labellisée par la Ligue contre le cancer, Institut Universitaire de France, Paris, France.; Université Paris-Saclay, INSERM US23 / CNRS UAR 3655, Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.; Université Paris Cité, Sorbonne Université, Inserm, Centre de Recherche des Cordeliers, Paris, France.; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France., Derosa L; Université Paris-Saclay, U1015 INSERM, Gustave Roussy, Ligue Labellisée contre le Cancer, Villejuif, France.; Gustave Roussy Cancer Campus (GRCC), ClinicObiome, Villejuif, France., Zitvogel L; Université Paris-Saclay, U1015 INSERM, Gustave Roussy, Ligue Labellisée contre le Cancer, Villejuif, France.; Gustave Roussy Cancer Campus (GRCC), ClinicObiome, Villejuif, France., Silverman M; Department of Medicine, Division of Infectious Diseases, Western University, London, Ontario, Canada.; Division of Infectious Diseases, St. Joseph's Health Care, London, Ontario, Canada.; Lawson Research Institute, London, Ontario, Canada., Segata N; Department of Computational, Cellular and Integrative Biology, University of Trento, Trento, Italy., Maleki Vareki S; Verspeeten Family Cancer Centre at London Health Sciences Centre, London, Ontario, Canada.; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.; Division of Experimental Oncology, Department of Oncology, Western University, London, Ontario, Canada.; Ontario Institute of Cancer Research, Toronto, Ontario, Canada., Routy B; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada.; Hemato-Oncology Division, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada., Elkrief A; Axe Cancer, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Québec, Canada. arielle.elkrief@umontreal.ca.; Hemato-Oncology Division, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada. arielle.elkrief@umontreal.ca. |
| Source: | Nature medicine [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1337-1350. Date of Electronic Publication: 2026 Jan 28. |
| Publication Type: | Journal Article; Clinical Trial, Phase II; Multicenter Study |
| Journal Info: | Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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