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Molecular requirements for PLK1 activation by T-loop phosphorylation.

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Title: Molecular requirements for PLK1 activation by T-loop phosphorylation.
Authors: Esposito-Verza A; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany. arianna.espositoverza@mpi-dortmund.mpg.de.; Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany. arianna.espositoverza@mpi-dortmund.mpg.de., Conti D; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany., Rodrigues Pedroso PD; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany.; i3S - Instituto de Investigação e Inovação em Saúde, Rua Alfredo Allen, 208, Porto, 4200-135, Portugal., Oberste-Lehn L; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany., Koerner C; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany., Wohlgemuth S; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany., Mansurkhodzhaev A; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany., Vetter IR; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany., Pesenti ME; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany., Musacchio A; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany. andrea.musacchio@mpi-dortmund.mpg.de.; Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany. andrea.musacchio@mpi-dortmund.mpg.de.
Source: The EMBO journal [EMBO J] 2026 Mar; Vol. 45 (5), pp. 1496-1536. Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: Molecular requirements for PLK1 activation by T-loop phosphorylation.
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  Data: <searchLink fieldCode="AU" term="%22Esposito-Verza+A%22">Esposito-Verza A</searchLink>; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany. arianna.espositoverza@mpi-dortmund.mpg.de.; Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany. arianna.espositoverza@mpi-dortmund.mpg.de.<br /><searchLink fieldCode="AU" term="%22Conti+D%22">Conti D</searchLink>; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany.<br /><searchLink fieldCode="AU" term="%22Rodrigues+Pedroso+PD%22">Rodrigues Pedroso PD</searchLink>; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany.; i3S - Instituto de Investigação e Inovação em Saúde, Rua Alfredo Allen, 208, Porto, 4200-135, Portugal.<br /><searchLink fieldCode="AU" term="%22Oberste-Lehn+L%22">Oberste-Lehn L</searchLink>; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany.<br /><searchLink fieldCode="AU" term="%22Koerner+C%22">Koerner C</searchLink>; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany.<br /><searchLink fieldCode="AU" term="%22Wohlgemuth+S%22">Wohlgemuth S</searchLink>; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany.<br /><searchLink fieldCode="AU" term="%22Mansurkhodzhaev+A%22">Mansurkhodzhaev A</searchLink>; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany.<br /><searchLink fieldCode="AU" term="%22Vetter+IR%22">Vetter IR</searchLink>; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany.<br /><searchLink fieldCode="AU" term="%22Pesenti+ME%22">Pesenti ME</searchLink>; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany.<br /><searchLink fieldCode="AU" term="%22Musacchio+A%22">Musacchio A</searchLink>; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, Dortmund, 44227, Germany. andrea.musacchio@mpi-dortmund.mpg.de.; Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany. andrea.musacchio@mpi-dortmund.mpg.de.
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