Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming.
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| Title: | Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming. |
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| Authors: | Wang Y; Department of Cardiovascular Genomics and Epigenomics, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Yinuo.Wang@medma.uni-heidelberg.de.; German Centre for Cardiovascular Research (DZHK), Heidelberg/Mannheim, Germany. Yinuo.Wang@medma.uni-heidelberg.de., Shi H; Department of Cardiovascular Genomics and Epigenomics, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Wittig J; Department of Vascular Dysfunction, ECAS, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany., Ren Y; Department of Cardiovascular Genomics and Epigenomics, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Cordero J; Department of Cardiovascular Genomics and Epigenomics, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Centre for Cardiovascular Research (DZHK), Heidelberg/Mannheim, Germany., Dewenter M; German Centre for Cardiovascular Research (DZHK), Heidelberg/Mannheim, Germany.; Institute of Experimental Cardiology, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany., Mella J; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA., Buchwalter A; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA., Backs J; German Centre for Cardiovascular Research (DZHK), Heidelberg/Mannheim, Germany.; Institute of Experimental Cardiology, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.; Helmholtz-Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University, Heidelberg, Germany., Wieland T; German Centre for Cardiovascular Research (DZHK), Heidelberg/Mannheim, Germany.; Experimental Pharmacology, ECAS, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Heineke J; German Centre for Cardiovascular Research (DZHK), Heidelberg/Mannheim, Germany.; Helmholtz-Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University, Heidelberg, Germany.; Department of Cardiovascular Physiology, ECAS, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Fleming I; German Centre for Cardiovascular Research (DZHK), Heidelberg/Mannheim, Germany.; Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany., Bibli SI; German Centre for Cardiovascular Research (DZHK), Heidelberg/Mannheim, Germany. Iris.Bibli@medma.uni-heidelberg.de.; Department of Vascular Dysfunction, ECAS, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Iris.Bibli@medma.uni-heidelberg.de.; Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany. Iris.Bibli@medma.uni-heidelberg.de.; Helmholtz-Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University, Heidelberg, Germany. Iris.Bibli@medma.uni-heidelberg.de., Dobreva G; Department of Cardiovascular Genomics and Epigenomics, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Gergana.Dobreva@medma.uni-heidelberg.de.; German Centre for Cardiovascular Research (DZHK), Heidelberg/Mannheim, Germany. Gergana.Dobreva@medma.uni-heidelberg.de.; Helmholtz-Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) at Heidelberg University, Heidelberg, Germany. Gergana.Dobreva@medma.uni-heidelberg.de. |
| Source: | Nature metabolism [Nat Metab] 2026 Feb; Vol. 8 (2), pp. 431-453. Date of Electronic Publication: 2026 Jan 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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