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Targeting CDC42 Protects Mitochondrial Function through KLF2/HIF-1α/PINK1 Signaling in Acute Kidney Injury.

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Title: Targeting CDC42 Protects Mitochondrial Function through KLF2/HIF-1α/PINK1 Signaling in Acute Kidney Injury.
Authors: Zhou X; Medical Examination Centre of the First Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Fu X; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Meng YW; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Dai P; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Jiang Q; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Yin HH; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Pan QJ; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Lin AZ; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Ni KD; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Luo ZG; Sci-Tech Innovation Center, Chongqing Medical University, Chongqing 400016, China., Liang RY; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Chen YY; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Yuan HX; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Liu JY; Medical Examination Centre of the First Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Department of Anesthesia of the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400061, China.
Source: International journal of biological sciences [Int J Biol Sci] 2026 Jan 01; Vol. 22 (3), pp. 1247-1265. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
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  Data: Targeting CDC42 Protects Mitochondrial Function through KLF2/HIF-1α/PINK1 Signaling in Acute Kidney Injury.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Medical Examination Centre of the First Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Fu+X%22">Fu X</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Meng+YW%22">Meng YW</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Dai+P%22">Dai P</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Jiang+Q%22">Jiang Q</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Yin+HH%22">Yin HH</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Pan+QJ%22">Pan QJ</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Lin+AZ%22">Lin AZ</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Ni+KD%22">Ni KD</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Luo+ZG%22">Luo ZG</searchLink>; Sci-Tech Innovation Center, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Liang+RY%22">Liang RY</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Chen+YY%22">Chen YY</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Yuan+HX%22">Yuan HX</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Liu+JY%22">Liu JY</searchLink>; Medical Examination Centre of the First Affiliated Hospital and CNTTI of College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.; Department of Anesthesia of the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400061, China.
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        Value: 10.7150/ijbs.125930
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