TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Disease.
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| Title: | TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Disease. |
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| Authors: | Shin EA; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee H; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Pyo KH; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim W; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim S; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee JH; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Jin SH; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim E; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Byeon SM; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim DJ; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Cho YJ; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim TW; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Ohn M; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee H; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee J; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Jeong J; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim D; Department of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon 21565, Republic of Korea., Zheng J; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee HA; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea., Kim HY; Department of Internal Medicine, Ewha Womans University College of Medicine, Division of Gastroenterology and Hepatology, Ewha Womans University Mokdong Hospital, Seoul 07985, Republic of Korea., Surh YJ; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee JW; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. |
| Source: | International journal of biological sciences [Int J Biol Sci] 2026 Jan 01; Vol. 22 (3), pp. 1103-1125. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41608638 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Shin+EA%22">Shin EA</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Pyo+KH%22">Pyo KH</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+W%22">Kim W</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jin+SH%22">Jin SH</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+E%22">Kim E</searchLink>; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Byeon+SM%22">Byeon SM</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+DJ%22">Kim DJ</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cho+YJ%22">Cho YJ</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+TW%22">Kim TW</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ohn+M%22">Ohn M</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeong+J%22">Jeong J</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+D%22">Kim D</searchLink>; Department of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon 21565, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Zheng+J%22">Zheng J</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+HA%22">Lee HA</searchLink>; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+HY%22">Kim HY</searchLink>; Department of Internal Medicine, Ewha Womans University College of Medicine, Division of Gastroenterology and Hepatology, Ewha Womans University Mokdong Hospital, Seoul 07985, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Surh+YJ%22">Surh YJ</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JW%22">Lee JW</searchLink>; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101235568%22">International journal of biological sciences</searchLink> [Int J Biol Sci] 2026 Jan 01; Vol. 22 (3), pp. 1103-1125. <i>Date of Electronic Publication: </i>2026 Jan 01 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ivyspring+International%22">Ivyspring International </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>101235568 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1449-2288 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214492288%22">14492288 </searchLink><i>NLM ISO Abbreviation: </i>Int J Biol Sci <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41608638 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.7150/ijbs.126251 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1103 Titles: – TitleFull: TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shin EA – PersonEntity: Name: NameFull: Lee H – PersonEntity: Name: NameFull: Pyo KH – PersonEntity: Name: NameFull: Kim W – PersonEntity: Name: NameFull: Kim S – PersonEntity: Name: NameFull: Lee JH – PersonEntity: Name: NameFull: Jin SH – PersonEntity: Name: NameFull: Kim E – PersonEntity: Name: NameFull: Byeon SM – PersonEntity: Name: NameFull: Kim DJ – PersonEntity: Name: NameFull: Cho YJ – PersonEntity: Name: NameFull: Kim TW – PersonEntity: Name: NameFull: Ohn M – PersonEntity: Name: NameFull: Lee H – PersonEntity: Name: NameFull: Lee J – PersonEntity: Name: NameFull: Jeong J – PersonEntity: Name: NameFull: Kim D – PersonEntity: Name: NameFull: Zheng J – PersonEntity: Name: NameFull: Lee HA – PersonEntity: Name: NameFull: Kim HY – PersonEntity: Name: NameFull: Surh YJ – PersonEntity: Name: NameFull: Lee JW IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Jan 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1449-2288 Numbering: – Type: volume Value: 22 – Type: issue Value: 3 Titles: – TitleFull: International journal of biological sciences Type: main |
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