TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Disease.
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| Title: | TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Disease. |
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| Authors: | Shin EA; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee H; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Pyo KH; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim W; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim S; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee JH; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Jin SH; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim E; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Byeon SM; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim DJ; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Cho YJ; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim TW; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Ohn M; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee H; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee J; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Jeong J; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Kim D; Department of Surgery, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon 21565, Republic of Korea., Zheng J; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee HA; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea., Kim HY; Department of Internal Medicine, Ewha Womans University College of Medicine, Division of Gastroenterology and Hepatology, Ewha Womans University Mokdong Hospital, Seoul 07985, Republic of Korea., Surh YJ; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Lee JW; Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. |
| Source: | International journal of biological sciences [Int J Biol Sci] 2026 Jan 01; Vol. 22 (3), pp. 1103-1125. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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