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Lactoferrin reduces febrile neutropenia in children receiving chemotherapy for hematologic malignancies: a randomized, placebo-controlled trial.

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Title: Lactoferrin reduces febrile neutropenia in children receiving chemotherapy for hematologic malignancies: a randomized, placebo-controlled trial.
Authors: Decembrino N; Neonatal Intensive Care Unit Unit-AOU Policlinico 'Rodolico-San Marco', University of Catania, 95100 Catania., Zama D; Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna. daniele.zama2@unibo.it., Muratore E; Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna. edoardo.muratore@studio.unibo.it., Muggeo P; Pediatric Hematology and Oncology, University Hospital of Policlinico, Bari., Perruccio K; Pediatric Hematology and Oncology Department, 'Santa Maria della Misericordia' Hospital, Perugia., Vitale V; Pediatric Hematology and Oncology, Department of the Mother and the Child, Azienda Ospedaliera Universitaria Integrata Verona., Colombini A; Paediatric Haematology/Oncology Fondazione Monza e Brianza per il Bambino e la Mamma, Monza., Kiren V; Paediatric Haematology/Oncology IRCCS Burlo Garofalo, Trieste., Mura R; Pediatric Hematology and Oncology Unit, ARNAS G. Brotzu Cagliari., De Santis R; Pediatric Hematology/Oncology, IRCCS Fondazione Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia., Recupero S; Paediatric Haematology/Oncology IRCCS San Matteo Hospital Foundation, Pavia., Masetti R; Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna., Tridello G; Pediatric Hematology and Oncology, Department of the Mother and the Child, Azienda Ospedaliera Universitaria Integrata Verona., Klersy C; Clinical Epidemiology and Biometry, IRCCS San Matteo Hospital Foundation, University of Pavia., Scudeller L; Clinical Epidemiology and Biometry, IRCCS San Matteo Hospital Foundation, University of Pavia., Zecca M; Paediatric Haematology/Oncology IRCCS San Matteo Hospital Foundation, Pavia., Cesaro S; Pediatric Hematology and Oncology, Department of the Mother and the Child, Azienda Ospedaliera Universitaria Integrata Verona.
Source: Haematologica [Haematologica] 2026 Jan 29. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lactoferrin reduces febrile neutropenia in children receiving chemotherapy for hematologic malignancies: a randomized, placebo-controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Decembrino+N%22">Decembrino N</searchLink>; Neonatal Intensive Care Unit Unit-AOU Policlinico 'Rodolico-San Marco', University of Catania, 95100 Catania.<br /><searchLink fieldCode="AU" term="%22Zama+D%22">Zama D</searchLink>; Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna. daniele.zama2@unibo.it.<br /><searchLink fieldCode="AU" term="%22Muratore+E%22">Muratore E</searchLink>; Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna. edoardo.muratore@studio.unibo.it.<br /><searchLink fieldCode="AU" term="%22Muggeo+P%22">Muggeo P</searchLink>; Pediatric Hematology and Oncology, University Hospital of Policlinico, Bari.<br /><searchLink fieldCode="AU" term="%22Perruccio+K%22">Perruccio K</searchLink>; Pediatric Hematology and Oncology Department, 'Santa Maria della Misericordia' Hospital, Perugia.<br /><searchLink fieldCode="AU" term="%22Vitale+V%22">Vitale V</searchLink>; Pediatric Hematology and Oncology, Department of the Mother and the Child, Azienda Ospedaliera Universitaria Integrata Verona.<br /><searchLink fieldCode="AU" term="%22Colombini+A%22">Colombini A</searchLink>; Paediatric Haematology/Oncology Fondazione Monza e Brianza per il Bambino e la Mamma, Monza.<br /><searchLink fieldCode="AU" term="%22Kiren+V%22">Kiren V</searchLink>; Paediatric Haematology/Oncology IRCCS Burlo Garofalo, Trieste.<br /><searchLink fieldCode="AU" term="%22Mura+R%22">Mura R</searchLink>; Pediatric Hematology and Oncology Unit, ARNAS G. Brotzu Cagliari.<br /><searchLink fieldCode="AU" term="%22De+Santis+R%22">De Santis R</searchLink>; Pediatric Hematology/Oncology, IRCCS Fondazione Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia.<br /><searchLink fieldCode="AU" term="%22Recupero+S%22">Recupero S</searchLink>; Paediatric Haematology/Oncology IRCCS San Matteo Hospital Foundation, Pavia.<br /><searchLink fieldCode="AU" term="%22Masetti+R%22">Masetti R</searchLink>; Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna.<br /><searchLink fieldCode="AU" term="%22Tridello+G%22">Tridello G</searchLink>; Pediatric Hematology and Oncology, Department of the Mother and the Child, Azienda Ospedaliera Universitaria Integrata Verona.<br /><searchLink fieldCode="AU" term="%22Klersy+C%22">Klersy C</searchLink>; Clinical Epidemiology and Biometry, IRCCS San Matteo Hospital Foundation, University of Pavia.<br /><searchLink fieldCode="AU" term="%22Scudeller+L%22">Scudeller L</searchLink>; Clinical Epidemiology and Biometry, IRCCS San Matteo Hospital Foundation, University of Pavia.<br /><searchLink fieldCode="AU" term="%22Zecca+M%22">Zecca M</searchLink>; Paediatric Haematology/Oncology IRCCS San Matteo Hospital Foundation, Pavia.<br /><searchLink fieldCode="AU" term="%22Cesaro+S%22">Cesaro S</searchLink>; Pediatric Hematology and Oncology, Department of the Mother and the Child, Azienda Ospedaliera Universitaria Integrata Verona.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ferrata+Storti+Foundation%22">Ferrata Storti Foundation </searchLink><i>Country of Publication: </i>Italy <i>NLM ID: </i>0417435 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1592-8721 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203906078%22">03906078 </searchLink><i>NLM ISO Abbreviation: </i>Haematologica <i>Subsets: </i>MEDLINE
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        Value: 10.3324/haematol.2025.300007
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        Text: English
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      – TitleFull: Lactoferrin reduces febrile neutropenia in children receiving chemotherapy for hematologic malignancies: a randomized, placebo-controlled trial.
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