Population pharmacokinetics model of pyrazinamide to optimize tuberculosis treatment: An interethnic cohort study of diabetes mellitus effect on drug exposure.

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Title: Population pharmacokinetics model of pyrazinamide to optimize tuberculosis treatment: An interethnic cohort study of diabetes mellitus effect on drug exposure.
Authors: Jayanti RP; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea., Cho YS; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Republic of Korea., Soedarsono S; Sub-Pumonology Department of Internal Medicine, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia.; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.; Dr. Soetomo General Hospital, Surabaya, Indonesia., Kim HJ; Division of Pulmonology, Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, Republic of Korea., Kang J; Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Republic of Korea., Kim J; Pulmonary Division, Department of Internal Medicine, Kosin University Gospel Hospital, Busan, Republic of Korea., Oh JY; Division of Pulmonology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Republic of Korea., Kang BH; Division of Pulmonology, Department of Internal Medicine, Dong-A University Hospital, Busan, Republic of Korea., Ha JH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Kim JW; Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Mertaniasih NM; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.; Departement of Clinical Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia., Kusmiati T; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.; Dr. Soetomo General Hospital, Surabaya, Indonesia., Permatasari A; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.; Dr. Soetomo General Hospital, Surabaya, Indonesia., Yuliwulandari R; Faculty of Medicine, University of Pembangunan Nasional Veteran Jawa Timur, Surabaya, Indonesia., Kim R; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea., Seong HJ; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea., Ghim JL; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Republic of Korea., Kim DH; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea., Shin JG; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Republic of Korea.
Corporate Authors: cPMTb
Source: PloS one [PLoS One] 2026 Jan 29; Vol. 21 (1), pp. e0340133. Date of Electronic Publication: 2026 Jan 29 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
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  Data: Population pharmacokinetics model of pyrazinamide to optimize tuberculosis treatment: An interethnic cohort study of diabetes mellitus effect on drug exposure.
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  Data: <searchLink fieldCode="AU" term="%22Jayanti+RP%22">Jayanti RP</searchLink>; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cho+YS%22">Cho YS</searchLink>; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Soedarsono+S%22">Soedarsono S</searchLink>; Sub-Pumonology Department of Internal Medicine, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia.; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.; Dr. Soetomo General Hospital, Surabaya, Indonesia.<br /><searchLink fieldCode="AU" term="%22Kim+HJ%22">Kim HJ</searchLink>; Division of Pulmonology, Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+J%22">Kang J</searchLink>; Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Pulmonary Division, Department of Internal Medicine, Kosin University Gospel Hospital, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+JY%22">Oh JY</searchLink>; Division of Pulmonology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+BH%22">Kang BH</searchLink>; Division of Pulmonology, Department of Internal Medicine, Dong-A University Hospital, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ha+JH%22">Ha JH</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+JW%22">Kim JW</searchLink>; Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Mertaniasih+NM%22">Mertaniasih NM</searchLink>; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.; Departement of Clinical Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.<br /><searchLink fieldCode="AU" term="%22Kusmiati+T%22">Kusmiati T</searchLink>; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.; Dr. Soetomo General Hospital, Surabaya, Indonesia.<br /><searchLink fieldCode="AU" term="%22Permatasari+A%22">Permatasari A</searchLink>; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.; Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.; Dr. Soetomo General Hospital, Surabaya, Indonesia.<br /><searchLink fieldCode="AU" term="%22Yuliwulandari+R%22">Yuliwulandari R</searchLink>; Faculty of Medicine, University of Pembangunan Nasional Veteran Jawa Timur, Surabaya, Indonesia.<br /><searchLink fieldCode="AU" term="%22Kim+R%22">Kim R</searchLink>; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Seong+HJ%22">Seong HJ</searchLink>; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ghim+JL%22">Ghim JL</searchLink>; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+DH%22">Kim DH</searchLink>; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Shin+JG%22">Shin JG</searchLink>; Center for Personalized Precision Medicine of Tuberculosis, Inje University College of Medicine, Busan, Republic of Korea.; Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Republic of Korea.
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  Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 Jan 29; Vol. 21 (1), pp. e0340133. <i>Date of Electronic Publication: </i>2026 Jan 29 (<i>Print Publication: </i>2026).
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