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A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis.

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Title: A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis.
Authors: Chua GNL; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY 10065, USA; Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA., Beckwitt EC; Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065, USA., Miller-Browne V; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; BCMB Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Yurieva O; Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA., Zhang D; Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065, USA., Katch BJ; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY 10065, USA; Tri-Institutional MD-PhD Program, Weill Cornell Medicine, The Rockefeller University, and Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Yao NY; Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065, USA., Watters JW; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY 10065, USA., Abrantes K; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY 10065, USA; Program in Physiology, Biophysics, and Systems Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Funabiki R; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY 10065, USA., Zhao X; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: zhaox1@mskcc.org., O'Donnell ME; Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. Electronic address: odonnel@rockefeller.edu., Liu S; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY 10065, USA. Electronic address: shixinliu@rockefeller.edu.
Source: Cell [Cell] 2026 Feb 19; Vol. 189 (4), pp. 1124-1134.e14. Date of Electronic Publication: 2026 Jan 28.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: A non-catalytic role for RFC in PCNA-mediated processive DNA synthesis.
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  Data: <searchLink fieldCode="AU" term="%22Chua+GNL%22">Chua GNL</searchLink>; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY 10065, USA; Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Beckwitt+EC%22">Beckwitt EC</searchLink>; Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Miller-Browne+V%22">Miller-Browne V</searchLink>; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; BCMB Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Yurieva+O%22">Yurieva O</searchLink>; Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Katch+BJ%22">Katch BJ</searchLink>; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY 10065, USA; Tri-Institutional MD-PhD Program, Weill Cornell Medicine, The Rockefeller University, and Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Yao+NY%22">Yao NY</searchLink>; Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Watters+JW%22">Watters JW</searchLink>; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Abrantes+K%22">Abrantes K</searchLink>; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY 10065, USA; Program in Physiology, Biophysics, and Systems Biology, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Funabiki+R%22">Funabiki R</searchLink>; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: zhaox1@mskcc.org.<br /><searchLink fieldCode="AU" term="%22O'Donnell+ME%22">O'Donnell ME</searchLink>; Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. Electronic address: odonnel@rockefeller.edu.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY 10065, USA. Electronic address: shixinliu@rockefeller.edu.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2026 Feb 19; Vol. 189 (4), pp. 1124-1134.e14. <i>Date of Electronic Publication: </i>2026 Jan 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0413066 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4172 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200928674%22">00928674 </searchLink><i>NLM ISO Abbreviation: </i>Cell <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb 19
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