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Benchmark White Matter Hyperintensity Segmentation Methods Fail on Heterogeneous Clinical MRI: A New Dataset and Deep Learning-Based Solutions.

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Title: Benchmark White Matter Hyperintensity Segmentation Methods Fail on Heterogeneous Clinical MRI: A New Dataset and Deep Learning-Based Solutions.
Authors: Wu J; Department of Neurology, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA. jwu40@emory.edu.; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA. jwu40@emory.edu., Brown JD; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA., Hu R; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA., Edwards PJ; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Levey AI; Department of Neurology, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA.; Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA., Lah JJ; Department of Neurology, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA.; Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA., Qiu D; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA. dqiu3@emory.edu.; Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA. dqiu3@emory.edu.; Joint Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA. dqiu3@emory.edu.
Source: Journal of imaging informatics in medicine [J Imaging Inform Med] 2026 Jan 29. Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Switzerland NLM ID: 9918663679206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2948-2933 (Electronic) Linking ISSN: 29482925 NLM ISO Abbreviation: J Imaging Inform Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Department of Neurology, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA. jwu40@emory.edu.; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA. jwu40@emory.edu.<br /><searchLink fieldCode="AU" term="%22Brown+JD%22">Brown JD</searchLink>; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA.<br /><searchLink fieldCode="AU" term="%22Hu+R%22">Hu R</searchLink>; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA.<br /><searchLink fieldCode="AU" term="%22Edwards+PJ%22">Edwards PJ</searchLink>; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Levey+AI%22">Levey AI</searchLink>; Department of Neurology, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA.; Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Lah+JJ%22">Lah JJ</searchLink>; Department of Neurology, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA.; Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Qiu+D%22">Qiu D</searchLink>; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA. dqiu3@emory.edu.; Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, GA, USA. dqiu3@emory.edu.; Joint Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA. dqiu3@emory.edu.
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              Text: 2026 Jan 29
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