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3D-bioprinted adipose-derived stem cell-secreted GAS6+-sEVs reprogram microglia polarization and alleviate neuroinflammation in traumatic brain injury.

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Title: 3D-bioprinted adipose-derived stem cell-secreted GAS6+-sEVs reprogram microglia polarization and alleviate neuroinflammation in traumatic brain injury.
Authors: Zhang Q; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China., Chen T; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China., Chen J; Bio-Intelligent Manufacturing and Living Matter Bioprinting Center, Research Institute of Tsinghua University in Shenzhen, Tsinghua University, Shenzhen, China., Ai Y; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China., Chen Z; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China., Liu G; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China., Zhang Y; Research and Development Department, Huamei Biotech Co. Ltd, Shenzhen, 518107, China., Liu B; Research and Development Department, Huamei Biotech Co. Ltd, Shenzhen, 518107, China., Liu J; School of Biomedical Sciences, the University of Queensland, Brisbane, Queensland, 4072, Australia., Tang Z; Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ, 07103, USA., Lin L; Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China., Chen X; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China., Xia Y; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. xiayuguo521@csu.edu.cn.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. xiayuguo521@csu.edu.cn.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China. xiayuguo521@csu.edu.cn.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. xiayuguo521@csu.edu.cn., Xu T; Bio-Intelligent Manufacturing and Living Matter Bioprinting Center, Research Institute of Tsinghua University in Shenzhen, Tsinghua University, Shenzhen, China. drtaoxu@yeah.net., Liu J; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. jinfang_liu@csu.edu.cn.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. jinfang_liu@csu.edu.cn.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China. jinfang_liu@csu.edu.cn.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. jinfang_liu@csu.edu.cn.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 Jan 30; Vol. 24 (1). Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: 3D-bioprinted adipose-derived stem cell-secreted GAS6<superscript>+</superscript>-sEVs reprogram microglia polarization and alleviate neuroinflammation in traumatic brain injury.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Chen+T%22">Chen T</searchLink>; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Bio-Intelligent Manufacturing and Living Matter Bioprinting Center, Research Institute of Tsinghua University in Shenzhen, Tsinghua University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Ai+Y%22">Ai Y</searchLink>; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Liu+G%22">Liu G</searchLink>; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Research and Development Department, Huamei Biotech Co. Ltd, Shenzhen, 518107, China.<br /><searchLink fieldCode="AU" term="%22Liu+B%22">Liu B</searchLink>; Research and Development Department, Huamei Biotech Co. Ltd, Shenzhen, 518107, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; School of Biomedical Sciences, the University of Queensland, Brisbane, Queensland, 4072, Australia.<br /><searchLink fieldCode="AU" term="%22Tang+Z%22">Tang Z</searchLink>; Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ, 07103, USA.<br /><searchLink fieldCode="AU" term="%22Lin+L%22">Lin L</searchLink>; Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.<br /><searchLink fieldCode="AU" term="%22Xia+Y%22">Xia Y</searchLink>; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. xiayuguo521@csu.edu.cn.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. xiayuguo521@csu.edu.cn.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China. xiayuguo521@csu.edu.cn.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. xiayuguo521@csu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xu+T%22">Xu T</searchLink>; Bio-Intelligent Manufacturing and Living Matter Bioprinting Center, Research Institute of Tsinghua University in Shenzhen, Tsinghua University, Shenzhen, China. drtaoxu@yeah.net.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. jinfang_liu@csu.edu.cn.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. jinfang_liu@csu.edu.cn.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China. jinfang_liu@csu.edu.cn.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. jinfang_liu@csu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101152208%22">Journal of nanobiotechnology</searchLink> [J Nanobiotechnology] 2026 Jan 30; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Jan 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101152208 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-3155 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214773155%22">14773155 </searchLink><i>NLM ISO Abbreviation: </i>J Nanobiotechnology <i>Subsets: </i>MEDLINE; In Process
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        Value: 10.1186/s12951-026-04064-3
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      – TitleFull: 3D-bioprinted adipose-derived stem cell-secreted GAS6+-sEVs reprogram microglia polarization and alleviate neuroinflammation in traumatic brain injury.
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