3D-bioprinted adipose-derived stem cell-secreted GAS6+-sEVs reprogram microglia polarization and alleviate neuroinflammation in traumatic brain injury.
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| Title: | 3D-bioprinted adipose-derived stem cell-secreted GAS6+-sEVs reprogram microglia polarization and alleviate neuroinflammation in traumatic brain injury. |
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| Authors: | Zhang Q; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China., Chen T; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China., Chen J; Bio-Intelligent Manufacturing and Living Matter Bioprinting Center, Research Institute of Tsinghua University in Shenzhen, Tsinghua University, Shenzhen, China., Ai Y; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China., Chen Z; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China., Liu G; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China., Zhang Y; Research and Development Department, Huamei Biotech Co. Ltd, Shenzhen, 518107, China., Liu B; Research and Development Department, Huamei Biotech Co. Ltd, Shenzhen, 518107, China., Liu J; School of Biomedical Sciences, the University of Queensland, Brisbane, Queensland, 4072, Australia., Tang Z; Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ, 07103, USA., Lin L; Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China., Chen X; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China., Xia Y; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. xiayuguo521@csu.edu.cn.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. xiayuguo521@csu.edu.cn.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China. xiayuguo521@csu.edu.cn.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. xiayuguo521@csu.edu.cn., Xu T; Bio-Intelligent Manufacturing and Living Matter Bioprinting Center, Research Institute of Tsinghua University in Shenzhen, Tsinghua University, Shenzhen, China. drtaoxu@yeah.net., Liu J; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. jinfang_liu@csu.edu.cn.; Research Institute of Brain and Spinal Cord Injury, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. jinfang_liu@csu.edu.cn.; Department of Neurosurgery, Xiangya School of Medicine, Central South University, Changsha, 410008, Hunan, China. jinfang_liu@csu.edu.cn.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. jinfang_liu@csu.edu.cn. |
| Source: | Journal of nanobiotechnology [J Nanobiotechnology] 2026 Jan 30; Vol. 24 (1). Date of Electronic Publication: 2026 Jan 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE; In Process |
| Database: | MEDLINE Ultimate |
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