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DHODH links mitochondrial bioenergetics, one-carbon metabolism, and DNA repair to sustain aggressive prostate adenocarcinoma.

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Title: DHODH links mitochondrial bioenergetics, one-carbon metabolism, and DNA repair to sustain aggressive prostate adenocarcinoma.
Authors: Rajaratnam S; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States., Piyarathna DWB; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States., Mehta RK; Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States., Mekala V; Epidemiology and Population Science, Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, United States., Park JH; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States., Rasaily U; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States., Venkatappa V; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States., Kami Reddy KR; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States., Putluri V; Advanced Technology cores, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States., Goel K; Department of Pathology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, United States., Grimm SL; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States., Thota SM; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States., Morrison T; Department of Pathology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, United States., Coarfa C; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States., Kaipparettu BA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States., Cheng C; Epidemiology and Population Science, Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, United States., Putluri N; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States.; Advanced Technology cores, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States., Jones JA; Michael E. DeBakey Veteran Affairs Medical Center, Houston, Texas, United States.; Department of Urology, Baylor College of Medicine, Houston, Texas, United States.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States., Nyati MK; Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States., Ittmann M; Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, United States., Gassman NR; Department of Pathology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, United States., Sreekumar A; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States. Arun.Sreekumar@bcm.edu.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States. Arun.Sreekumar@bcm.edu.
Source: Cell communication and signaling : CCS [Cell Commun Signal] 2026 Jan 29; Vol. 24 (1). Date of Electronic Publication: 2026 Jan 29.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE
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  Data: DHODH links mitochondrial bioenergetics, one-carbon metabolism, and DNA repair to sustain aggressive prostate adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Rajaratnam+S%22">Rajaratnam S</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Piyarathna+DWB%22">Piyarathna DWB</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Mehta+RK%22">Mehta RK</searchLink>; Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States.<br /><searchLink fieldCode="AU" term="%22Mekala+V%22">Mekala V</searchLink>; Epidemiology and Population Science, Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Park+JH%22">Park JH</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Rasaily+U%22">Rasaily U</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Venkatappa+V%22">Venkatappa V</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Kami+Reddy+KR%22">Kami Reddy KR</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Putluri+V%22">Putluri V</searchLink>; Advanced Technology cores, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Goel+K%22">Goel K</searchLink>; Department of Pathology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, United States.<br /><searchLink fieldCode="AU" term="%22Grimm+SL%22">Grimm SL</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Thota+SM%22">Thota SM</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Morrison+T%22">Morrison T</searchLink>; Department of Pathology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, United States.<br /><searchLink fieldCode="AU" term="%22Coarfa+C%22">Coarfa C</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Kaipparettu+BA%22">Kaipparettu BA</searchLink>; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Cheng+C%22">Cheng C</searchLink>; Epidemiology and Population Science, Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Putluri+N%22">Putluri N</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States.; Advanced Technology cores, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Jones+JA%22">Jones JA</searchLink>; Michael E. DeBakey Veteran Affairs Medical Center, Houston, Texas, United States.; Department of Urology, Baylor College of Medicine, Houston, Texas, United States.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Nyati+MK%22">Nyati MK</searchLink>; Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States.<br /><searchLink fieldCode="AU" term="%22Ittmann+M%22">Ittmann M</searchLink>; Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Gassman+NR%22">Gassman NR</searchLink>; Department of Pathology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, United States.<br /><searchLink fieldCode="AU" term="%22Sreekumar+A%22">Sreekumar A</searchLink>; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States. Arun.Sreekumar@bcm.edu.; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, United States. Arun.Sreekumar@bcm.edu.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101170464 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1478-811X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221478811X%22">1478811X </searchLink><i>NLM ISO Abbreviation: </i>Cell Commun Signal <i>Subsets: </i>MEDLINE
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