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A pragmatic trial with an optimized dose of rifampicin and moxifloxacin for the treatment of drug-susceptible pulmonary tuberculosis: a study protocol for open-label, randomized phase III trial (OptiRiMoxTB).

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Title: A pragmatic trial with an optimized dose of rifampicin and moxifloxacin for the treatment of drug-susceptible pulmonary tuberculosis: a study protocol for open-label, randomized phase III trial (OptiRiMoxTB).
Authors: Mlyuka HJ; Muhimbili University of Health and Allied Sciences, PO Box 65013, Dar Es Salaam, Tanzania., Liyoyo A; Kibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania., Nyaulingo B; Kibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania., Mpolya E; Department of Global Health and Biomedical Sciences, Nelson Mandela African Institution of Science and Technology, Tengeru, Arusha, Tanzania., Kaswaga OL; Kibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania., Semvua H; Kilimanjaro Clinical Research Institute, Moshi, Tanzania., Lwambura S; Ifakara Health Institute, Dar Es Salaam, Tanzania., McHugh TD; Division of Infection & Immunity, UCL Centre for Clinical Microbiology, University College London, London, UK., Wildner L; Division of Infection & Immunity, UCL Centre for Clinical Microbiology, University College London, London, UK., Sabiiti W; School of Medicine, University of St Andrews, St Andrews, Scotland, UK., Adegbite BR; Centre de Recherches Médicales de Lambaréné, Lambarene, Gabon., Nliwasa M; Kamuzu University of Health Sciences, Blantyre, Malawi., Khosa C; Instituto Nacional de Saúde, Maputo, Mozambique., Mbelele P; Kibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania., Mbeya B; Ifakara Health Institute, Dar Es Salaam, Tanzania., Jeremiah K; National Institute for Medical Research, Mwanza, Tanzania., Boeree MJ; Radboud University Medical Center, Nijmegen, The Netherlands., Gillespie SH; School of Medicine, University of St Andrews, St Andrews, Scotland, UK., Sloan DJ; School of Medicine, University of St Andrews, St Andrews, Scotland, UK.; Radboud University Medical Center, Nijmegen, The Netherlands.; Victoria Hospital, NHS Fife, Kirkcaldy, Scotland, UK., Mpagama SG; Department of Global Health and Biomedical Sciences, Nelson Mandela African Institution of Science and Technology, Tengeru, Arusha, Tanzania. stella.mpagama@kidh.go.tz.
Corporate Authors: SimpliciTB Consortium
Source: Trials [Trials] 2026 Jan 30; Vol. 27 (1). Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A pragmatic trial with an optimized dose of rifampicin and moxifloxacin for the treatment of drug-susceptible pulmonary tuberculosis: a study protocol for open-label, randomized phase III trial (OptiRiMoxTB).
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  Data: <searchLink fieldCode="AU" term="%22Mlyuka+HJ%22">Mlyuka HJ</searchLink>; Muhimbili University of Health and Allied Sciences, PO Box 65013, Dar Es Salaam, Tanzania.<br /><searchLink fieldCode="AU" term="%22Liyoyo+A%22">Liyoyo A</searchLink>; Kibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania.<br /><searchLink fieldCode="AU" term="%22Nyaulingo+B%22">Nyaulingo B</searchLink>; Kibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania.<br /><searchLink fieldCode="AU" term="%22Mpolya+E%22">Mpolya E</searchLink>; Department of Global Health and Biomedical Sciences, Nelson Mandela African Institution of Science and Technology, Tengeru, Arusha, Tanzania.<br /><searchLink fieldCode="AU" term="%22Kaswaga+OL%22">Kaswaga OL</searchLink>; Kibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania.<br /><searchLink fieldCode="AU" term="%22Semvua+H%22">Semvua H</searchLink>; Kilimanjaro Clinical Research Institute, Moshi, Tanzania.<br /><searchLink fieldCode="AU" term="%22Lwambura+S%22">Lwambura S</searchLink>; Ifakara Health Institute, Dar Es Salaam, Tanzania.<br /><searchLink fieldCode="AU" term="%22McHugh+TD%22">McHugh TD</searchLink>; Division of Infection & Immunity, UCL Centre for Clinical Microbiology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wildner+L%22">Wildner L</searchLink>; Division of Infection & Immunity, UCL Centre for Clinical Microbiology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sabiiti+W%22">Sabiiti W</searchLink>; School of Medicine, University of St Andrews, St Andrews, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Adegbite+BR%22">Adegbite BR</searchLink>; Centre de Recherches Médicales de Lambaréné, Lambarene, Gabon.<br /><searchLink fieldCode="AU" term="%22Nliwasa+M%22">Nliwasa M</searchLink>; Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Khosa+C%22">Khosa C</searchLink>; Instituto Nacional de Saúde, Maputo, Mozambique.<br /><searchLink fieldCode="AU" term="%22Mbelele+P%22">Mbelele P</searchLink>; Kibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania.<br /><searchLink fieldCode="AU" term="%22Mbeya+B%22">Mbeya B</searchLink>; Ifakara Health Institute, Dar Es Salaam, Tanzania.<br /><searchLink fieldCode="AU" term="%22Jeremiah+K%22">Jeremiah K</searchLink>; National Institute for Medical Research, Mwanza, Tanzania.<br /><searchLink fieldCode="AU" term="%22Boeree+MJ%22">Boeree MJ</searchLink>; Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gillespie+SH%22">Gillespie SH</searchLink>; School of Medicine, University of St Andrews, St Andrews, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Sloan+DJ%22">Sloan DJ</searchLink>; School of Medicine, University of St Andrews, St Andrews, Scotland, UK.; Radboud University Medical Center, Nijmegen, The Netherlands.; Victoria Hospital, NHS Fife, Kirkcaldy, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Mpagama+SG%22">Mpagama SG</searchLink>; Department of Global Health and Biomedical Sciences, Nelson Mandela African Institution of Science and Technology, Tengeru, Arusha, Tanzania. stella.mpagama@kidh.go.tz.
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  Data: <searchLink fieldCode="CA" term="%22SimpliciTB+Consortium%22">SimpliciTB Consortium</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101263253%22">Trials</searchLink> [Trials] 2026 Jan 30; Vol. 27 (1). <i>Date of Electronic Publication: </i>2026 Jan 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101263253 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-6215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217456215%22">17456215 </searchLink><i>NLM ISO Abbreviation: </i>Trials <i>Subsets: </i>MEDLINE
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