A pragmatic trial with an optimized dose of rifampicin and moxifloxacin for the treatment of drug-susceptible pulmonary tuberculosis: a study protocol for open-label, randomized phase III trial (OptiRiMoxTB).
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| Title: | A pragmatic trial with an optimized dose of rifampicin and moxifloxacin for the treatment of drug-susceptible pulmonary tuberculosis: a study protocol for open-label, randomized phase III trial (OptiRiMoxTB). |
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| Authors: | Mlyuka HJ; Muhimbili University of Health and Allied Sciences, PO Box 65013, Dar Es Salaam, Tanzania., Liyoyo A; Kibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania., Nyaulingo B; Kibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania., Mpolya E; Department of Global Health and Biomedical Sciences, Nelson Mandela African Institution of Science and Technology, Tengeru, Arusha, Tanzania., Kaswaga OL; Kibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania., Semvua H; Kilimanjaro Clinical Research Institute, Moshi, Tanzania., Lwambura S; Ifakara Health Institute, Dar Es Salaam, Tanzania., McHugh TD; Division of Infection & Immunity, UCL Centre for Clinical Microbiology, University College London, London, UK., Wildner L; Division of Infection & Immunity, UCL Centre for Clinical Microbiology, University College London, London, UK., Sabiiti W; School of Medicine, University of St Andrews, St Andrews, Scotland, UK., Adegbite BR; Centre de Recherches Médicales de Lambaréné, Lambarene, Gabon., Nliwasa M; Kamuzu University of Health Sciences, Blantyre, Malawi., Khosa C; Instituto Nacional de Saúde, Maputo, Mozambique., Mbelele P; Kibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania., Mbeya B; Ifakara Health Institute, Dar Es Salaam, Tanzania., Jeremiah K; National Institute for Medical Research, Mwanza, Tanzania., Boeree MJ; Radboud University Medical Center, Nijmegen, The Netherlands., Gillespie SH; School of Medicine, University of St Andrews, St Andrews, Scotland, UK., Sloan DJ; School of Medicine, University of St Andrews, St Andrews, Scotland, UK.; Radboud University Medical Center, Nijmegen, The Netherlands.; Victoria Hospital, NHS Fife, Kirkcaldy, Scotland, UK., Mpagama SG; Department of Global Health and Biomedical Sciences, Nelson Mandela African Institution of Science and Technology, Tengeru, Arusha, Tanzania. stella.mpagama@kidh.go.tz. |
| Corporate Authors: | SimpliciTB Consortium |
| Source: | Trials [Trials] 2026 Jan 30; Vol. 27 (1). Date of Electronic Publication: 2026 Jan 30. |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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