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Relationship between age and severity of cognitive impairment at diagnosis for early-onset and late-onset Alzheimer's disease: Comparison of LEADS and ADNI.

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Title: Relationship between age and severity of cognitive impairment at diagnosis for early-onset and late-onset Alzheimer's disease: Comparison of LEADS and ADNI.
Authors: Hammers DB; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Eloyan A; Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA., Thangarajah M; Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA., Taurone A; Department of Biostatistics, Center for Statistical Sciences, Brown University, Providence, Rhode Island, USA., Gao S; Department of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Beckett L; Department of Public Health Sciences, University of California-Davis, Davis, California, USA., Kirby K; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Dage JL; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Nudelman K; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Aisen P; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA., Reman R; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA., Vemuri P; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA., La Joie R; Department of Neurology, University of California-San Francisco, San Francisco, California, USA., Touroutoglou A; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Atri A; Banner Sun Health Research Institute, Sun City, Arizona, USA., Clark D; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Day GS; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Duara R; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami, Florida, USA., Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Honig LS; Taub Institute and Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA., Jones DT; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA., Masdeu JC; Nantz National Alzheimer Center, Houston Methodist and Weill Cornell Medicine, Houston, Texas, USA., Mendez MF; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Womack K; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA., Musiek E; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA., Onyike CU; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Riddle M; Department of Neurology, Alpert Medical School, Brown University, Providence, Rhode Island, USA., Grant I; Department of Psychiatry and Behavioral Sciences, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA., Rogalski E; Healthy Aging & Alzheimer's Research Care Center, Department of Neurology, University of Chicago, Chicago, Illinois, USA., Johnson ECB; Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA., Salloway S; Department of Neurology, Alpert Medical School, Brown University, Providence, Rhode Island, USA., Sha SJ; Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, California, USA., Turner RS; Department of Neurology, Georgetown University, Washington D.C., USA., Wingo TS; Department of Neurology, UC Davis Alzheimer's Disease Research Center, University of California-Davis, Davis, California, USA., Wolk DA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Carrillo MC; Medical & Scientific Relations Division, Alzheimer's Association, Chicago, Illinois, USA., Dickerson BC; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Rabinovici GD; Department of Neurology, University of California-San Francisco, San Francisco, California, USA.; Department of Radiology & Biomedical Imaging, University of California-San Francisco, San Francisco, California, USA., Apostolova LG; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana, USA.
Corporate Authors: LEADS Consortium; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Alzheimer's Disease Neuroimaging Initiative
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Feb; Vol. 22 (2), pp. e71160.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Relationship between age and severity of cognitive impairment at diagnosis for early-onset and late-onset Alzheimer's disease: Comparison of LEADS and ADNI.
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Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Dage+JL%22">Dage JL</searchLink>; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Nudelman+K%22">Nudelman K</searchLink>; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Aisen+P%22">Aisen P</searchLink>; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Reman+R%22">Reman R</searchLink>; Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Vemuri+P%22">Vemuri P</searchLink>; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22La+Joie+R%22">La Joie R</searchLink>; Department of Neurology, University of California-San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Touroutoglou+A%22">Touroutoglou A</searchLink>; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Atri+A%22">Atri A</searchLink>; Banner Sun Health Research Institute, Sun City, Arizona, USA.<br /><searchLink fieldCode="AU" term="%22Clark+D%22">Clark D</searchLink>; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Day+GS%22">Day GS</searchLink>; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Duara+R%22">Duara R</searchLink>; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Graff-Radford+NR%22">Graff-Radford NR</searchLink>; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Honig+LS%22">Honig LS</searchLink>; Taub Institute and Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Jones+DT%22">Jones DT</searchLink>; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Masdeu+JC%22">Masdeu JC</searchLink>; Nantz National Alzheimer Center, Houston Methodist and Weill Cornell Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Mendez+MF%22">Mendez MF</searchLink>; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Womack+K%22">Womack K</searchLink>; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Musiek+E%22">Musiek E</searchLink>; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Onyike+CU%22">Onyike CU</searchLink>; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Riddle+M%22">Riddle M</searchLink>; Department of Neurology, Alpert Medical School, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Grant+I%22">Grant I</searchLink>; Department of Psychiatry and Behavioral Sciences, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Rogalski+E%22">Rogalski E</searchLink>; Healthy Aging & Alzheimer's Research Care Center, Department of Neurology, University of Chicago, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+ECB%22">Johnson ECB</searchLink>; Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Salloway+S%22">Salloway S</searchLink>; Department of Neurology, Alpert Medical School, Brown University, Providence, Rhode Island, USA.<br /><searchLink fieldCode="AU" term="%22Sha+SJ%22">Sha SJ</searchLink>; Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Turner+RS%22">Turner RS</searchLink>; Department of Neurology, Georgetown University, Washington D.C., USA.<br /><searchLink fieldCode="AU" term="%22Wingo+TS%22">Wingo TS</searchLink>; Department of Neurology, UC Davis Alzheimer's Disease Research Center, University of California-Davis, Davis, California, USA.<br /><searchLink fieldCode="AU" term="%22Wolk+DA%22">Wolk DA</searchLink>; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Carrillo+MC%22">Carrillo MC</searchLink>; Medical & Scientific Relations Division, Alzheimer's Association, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Dickerson+BC%22">Dickerson BC</searchLink>; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Rabinovici+GD%22">Rabinovici GD</searchLink>; Department of Neurology, University of California-San Francisco, San Francisco, California, USA.; Department of Radiology & Biomedical Imaging, University of California-San Francisco, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Apostolova+LG%22">Apostolova LG</searchLink>; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine Indianapolis, Indianapolis, Indiana, USA.
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  Data: <searchLink fieldCode="CA" term="%22LEADS+Consortium%22">LEADS Consortium</searchLink>; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="CA" term="%22Alzheimer's+Disease+Neuroimaging+Initiative%22">Alzheimer's Disease Neuroimaging Initiative</searchLink>
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