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A stage of mechanisms of pathological cerebral blood flow reduction due to severe central hypovolemia: a study using maximal lower body negative pressure.

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Title: A stage of mechanisms of pathological cerebral blood flow reduction due to severe central hypovolemia: a study using maximal lower body negative pressure.
Authors: Hirasawa A; Department of Health and Welfare, Faculty of Health Sciences, Kyorin University, Tokyo, Japan., Washio T; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, United States.; Southwestern Medical Center, University of Texas, Dallas, Texas, United States., Suda T; Department of General Medicine, Faculty of Medicine, Kyorin University, Tokyo, Japan., Hirabuki K; Department of General Medicine, Faculty of Medicine, Kyorin University, Tokyo, Japan., Fukuie M; Human Informatics Research Institute, The National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan., Saito S; Department of Biomedical Engineering, Toyo University, Saitama, Japan., Hata N; Department of General Medicine, Faculty of Medicine, Kyorin University, Tokyo, Japan., Matsuda T; Department of General Medicine, Faculty of Medicine, Kyorin University, Tokyo, Japan., Sugawara J; Human Informatics Research Institute, The National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan., Ogoh S; Department of Biomedical Engineering, Toyo University, Saitama, Japan., Shibata S; Department of Physical Therapy, Faculty of Health Science, Kyorin University, Tokyo, Japan.
Source: American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2026 Apr 01; Vol. 330 (4), pp. R301-R309. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Hirasawa+A%22">Hirasawa A</searchLink>; Department of Health and Welfare, Faculty of Health Sciences, Kyorin University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Washio+T%22">Washio T</searchLink>; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, United States.; Southwestern Medical Center, University of Texas, Dallas, Texas, United States.<br /><searchLink fieldCode="AU" term="%22Suda+T%22">Suda T</searchLink>; Department of General Medicine, Faculty of Medicine, Kyorin University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hirabuki+K%22">Hirabuki K</searchLink>; Department of General Medicine, Faculty of Medicine, Kyorin University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuie+M%22">Fukuie M</searchLink>; Human Informatics Research Institute, The National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+S%22">Saito S</searchLink>; Department of Biomedical Engineering, Toyo University, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Hata+N%22">Hata N</searchLink>; Department of General Medicine, Faculty of Medicine, Kyorin University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuda+T%22">Matsuda T</searchLink>; Department of General Medicine, Faculty of Medicine, Kyorin University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sugawara+J%22">Sugawara J</searchLink>; Human Informatics Research Institute, The National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Ogoh+S%22">Ogoh S</searchLink>; Department of Biomedical Engineering, Toyo University, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Shibata+S%22">Shibata S</searchLink>; Department of Physical Therapy, Faculty of Health Science, Kyorin University, Tokyo, Japan.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Physiological+Society%22">American Physiological Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100901230 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-1490 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203636119%22">03636119 </searchLink><i>NLM ISO Abbreviation: </i>Am J Physiol Regul Integr Comp Physiol <i>Subsets: </i>MEDLINE
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        Value: 10.1152/ajpregu.00181.2025
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        Text: English
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              Text: 2026 Apr 01
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