Effectiveness of Long-Acting Injectable Antipsychotics Versus Oral Antipsychotics in People With Bipolar Disorder: A Systematic Review and Meta-Analysis of Observational Studies: Efficacité des antipsychotiques injectables à action prolongée par rapport aux antipsychotiques oraux chez les personnes atteintes de troubles bipolaires : revue systématique et méta-analyse d'études observationnelles.

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Title: Effectiveness of Long-Acting Injectable Antipsychotics Versus Oral Antipsychotics in People With Bipolar Disorder: A Systematic Review and Meta-Analysis of Observational Studies: Efficacité des antipsychotiques injectables à action prolongée par rapport aux antipsychotiques oraux chez les personnes atteintes de troubles bipolaires : revue systématique et méta-analyse d'études observationnelles.
Authors: Wagner E; Evidence-Based Psychiatry and Psychotherapy, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany., Katyal S; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada., Lee IO; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada., Tasnim S; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada., El Wadia H; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada., Mortazavi M; Evidence-Based Psychiatry and Psychotherapy, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany., García-Carmona JA; Department of Neurology, Santa Lucía University Hospital, Murcia, Spain.; Group of Clinical and Experimental Pharmacology, Institute for Biomedical Research of Murcia (IMIB), Murcia, Spain.; Faculty of Pharmacy and Nutrition, San Antonio Catholic University of Murcia (UCAM), Murcia, Spain., Hasan A; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics Augsburg, DZPG (German Center for Mental Health), Augsburg, Germany., Colman I; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada., Taipale H; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden.; Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland.; School of Pharmacy, University of Eastern Finland, Kuopio, Finland., Tiihonen J; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden.; Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland., Correll CU; Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY, USA.; Departments of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.; German Center for Mental Health (DZPG), Partner Site Berlin, Berlin, Germany., Højlund M; Department of Psychiatry Aabenraa, Mental Health Services Region of Southern Denmark, Aabenraa, Denmark.; Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark., Solmi M; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.; SCIENCES Lab, Department of Psychiatry, University of Ottawa, Ontario, Canada.; Regional Centre for the Treatment of Eating Disorders and On Track: The Champlain First Episode Psychosis Program, Department of Mental Health, The Ottawa Hospital, Ontario, Canada.; Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada.
Source: Canadian journal of psychiatry. Revue canadienne de psychiatrie [Can J Psychiatry] 2026 Jun; Vol. 71 (6), pp. 420-435. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article; Systematic Review; Meta-Analysis; Comparative Study; Review
Journal Info: Publisher: Sage Country of Publication: United States NLM ID: 7904187 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1497-0015 (Electronic) Linking ISSN: 07067437 NLM ISO Abbreviation: Can J Psychiatry Subsets: MEDLINE
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  Data: Effectiveness of Long-Acting Injectable Antipsychotics Versus Oral Antipsychotics in People With Bipolar Disorder: A Systematic Review and Meta-Analysis of Observational Studies: Efficacité des antipsychotiques injectables à action prolongée par rapport aux antipsychotiques oraux chez les personnes atteintes de troubles bipolaires : revue systématique et méta-analyse d'études observationnelles.
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  Data: <searchLink fieldCode="AU" term="%22Wagner+E%22">Wagner E</searchLink>; Evidence-Based Psychiatry and Psychotherapy, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Katyal+S%22">Katyal S</searchLink>; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+IO%22">Lee IO</searchLink>; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.<br /><searchLink fieldCode="AU" term="%22Tasnim+S%22">Tasnim S</searchLink>; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.<br /><searchLink fieldCode="AU" term="%22El+Wadia+H%22">El Wadia H</searchLink>; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.<br /><searchLink fieldCode="AU" term="%22Mortazavi+M%22">Mortazavi M</searchLink>; Evidence-Based Psychiatry and Psychotherapy, Faculty of Medicine, University of Augsburg, Augsburg, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22García-Carmona+JA%22">García-Carmona JA</searchLink>; Department of Neurology, Santa Lucía University Hospital, Murcia, Spain.; Group of Clinical and Experimental Pharmacology, Institute for Biomedical Research of Murcia (IMIB), Murcia, Spain.; Faculty of Pharmacy and Nutrition, San Antonio Catholic University of Murcia (UCAM), Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Hasan+A%22">Hasan A</searchLink>; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty, University of Augsburg, Augsburg, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics Augsburg, DZPG (German Center for Mental Health), Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Colman+I%22">Colman I</searchLink>; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.<br /><searchLink fieldCode="AU" term="%22Taipale+H%22">Taipale H</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden.; Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland.; School of Pharmacy, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Tiihonen+J%22">Tiihonen J</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden.; Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Correll+CU%22">Correll CU</searchLink>; Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY, USA.; Departments of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.; German Center for Mental Health (DZPG), Partner Site Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Højlund+M%22">Højlund M</searchLink>; Department of Psychiatry Aabenraa, Mental Health Services Region of Southern Denmark, Aabenraa, Denmark.; Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Solmi+M%22">Solmi M</searchLink>; School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.; SCIENCES Lab, Department of Psychiatry, University of Ottawa, Ontario, Canada.; Regional Centre for the Treatment of Eating Disorders and On Track: The Champlain First Episode Psychosis Program, Department of Mental Health, The Ottawa Hospital, Ontario, Canada.; Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada.
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