International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema.

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Title: International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema.
Authors: Farkas H; Hungarian Angioedema Centre of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary., Martinez-Saguer I; HZRM Heamophilia Centre Rein Main, Frankfurt, Germany., Bork K; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany., Germenis AE; Department of Immunology & Histocombatibility, School of Medicine, University of Thessaly, Larissa, Greece., Grumach AS; Clinical Immunology, Centro Universitario Faculdade de Medicina do ABC, Santo Andre, Brazil., Horváth HR; Hungarian Angioedema Centre of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary., Luczay A; Pediatric Center Semmelweis University, Budapest, Hungary., Zanichelli A; Operative Unit of Medicine, Angioedema Center, IRCCS Policlinico San Donato, Milan, Italy.; Dipartimento di Scienze Biomediche Per la Salute, University of Milan, Milan, Italy., Magerl M; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany., Betschel S; Division of Clinical Immunology and Allergy, Department of Medicine, Unity Health, University of Toronto, Toronto, Ontario, Canada., Aygören-Pürsün E; Department of Pediatrics, University Hospital, Goethe University, Frankfurt am Main, Germany., Bernstein JA; Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, University of Cincinnati College of Medicine, Partner of Advanced Allergy Services and Bernstein Clinical Research Center, Cincinnati, Ohio, USA., Boccon-Gibod I; Clinical Immunology and Internal Medicine Department, National Reference Centre for Angioedema (CREAK) and ACARE Centre of Reference and Excellence, Grenoble Alpes University Hospital, Grenoble, France., Caballero T; Department of Allergy, Hospital Universitario La Paz, Hospital La Paz Health Research Institute (IdiPAZ), biomedical Research Network on Rare Diseases (CIBERER, U754), Madrid, Spain., Cancian M; Department of Systems Medicine, University Hospital of Padua, Padua, Italy., Christiansen S; Division of Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA., Cohn DM; Amsterdam UMC, Cardiovascular Sciences, Department of Vascular Medicine, University of Amsterdam, Amsterdam, the Netherlands., Contreras F; Allergy Service, National Institute of Pediatrics, Mexico City, Mexico., Craig S; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Isaic C; HAE Junior Patient Organization, Prague, Czech Republic., Jindal A; Pediatric Clinical Immunology and Rheumatology, Department of Pediatrics, Manipal Hospital, Bengaluru, India., Katelaris CH; Immunology & Allergy Unit Campbelltown Hospital and Western Sydney University, Sydney, New South Wales, Australia., Longhurst HJ; Department of Immunology, Auckland City Hospital and University of Auckland, Auckland, New Zealand., MacGinnitie A; Division of Allergy, Asthma, and Immunology, Children's Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Peter J; Division of Allergy and Clinical Immunology, Groote Schuur Hospital, University of Cape Town, Rondebosch, South Africa.; Allergy and Immunology Unit, University of Cape Town Lung Institute, Rondebosch, South Africa., Porebski G; Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland., Reshef A; Angioedema Research Center, Barzilai University Medical Center, Ashkelon, Israel., Van Nguyen D; Vinmec-VinUni Institute of Immunology, VinUniversity, Hanoi, Vietnam.; Center of Allergy and Clinical Immunology, Vinmec Times City, Vinmec Healthcare System, Hanoi, Vietnam.; College of Medicine, Penn State University, Hershey, Pennsylvania, USA., Zuraw B; Division of Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.; Medicine Service, Veterans Administration Healthcare, San Diego, California, USA., Castaldo AJ; Hereditary Angioedema International, USA., Boysen HB; Hereditary Angioedema International, USA., Craig T; Department of Medicine, Pediatrics, OB/GYN MFM, and Biomedical Sciences, Penn State University, Hershey, Pennsylvania, USA.; Vin-Mec-VinUni Institute of Immunology, Vin University, Hanoi, Vietnam.
Corporate Authors: Hereditary Angioedema Working Group (HAWK Group)
Source: Allergy [Allergy] 2026 Jan 30. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article; Review
Journal Info: Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 7804028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1398-9995 (Electronic) Linking ISSN: 01054538 NLM ISO Abbreviation: Allergy Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema.
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  Data: <searchLink fieldCode="AU" term="%22Farkas+H%22">Farkas H</searchLink>; Hungarian Angioedema Centre of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Martinez-Saguer+I%22">Martinez-Saguer I</searchLink>; HZRM Heamophilia Centre Rein Main, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Bork+K%22">Bork K</searchLink>; Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Germenis+AE%22">Germenis AE</searchLink>; Department of Immunology & Histocombatibility, School of Medicine, University of Thessaly, Larissa, Greece.<br /><searchLink fieldCode="AU" term="%22Grumach+AS%22">Grumach AS</searchLink>; Clinical Immunology, Centro Universitario Faculdade de Medicina do ABC, Santo Andre, Brazil.<br /><searchLink fieldCode="AU" term="%22Horváth+HR%22">Horváth HR</searchLink>; Hungarian Angioedema Centre of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Luczay+A%22">Luczay A</searchLink>; Pediatric Center Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Zanichelli+A%22">Zanichelli A</searchLink>; Operative Unit of Medicine, Angioedema Center, IRCCS Policlinico San Donato, Milan, Italy.; Dipartimento di Scienze Biomediche Per la Salute, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Magerl+M%22">Magerl M</searchLink>; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Betschel+S%22">Betschel S</searchLink>; Division of Clinical Immunology and Allergy, Department of Medicine, Unity Health, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Aygören-Pürsün+E%22">Aygören-Pürsün E</searchLink>; Department of Pediatrics, University Hospital, Goethe University, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Bernstein+JA%22">Bernstein JA</searchLink>; Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, University of Cincinnati College of Medicine, Partner of Advanced Allergy Services and Bernstein Clinical Research Center, Cincinnati, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Boccon-Gibod+I%22">Boccon-Gibod I</searchLink>; Clinical Immunology and Internal Medicine Department, National Reference Centre for Angioedema (CREAK) and ACARE Centre of Reference and Excellence, Grenoble Alpes University Hospital, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Caballero+T%22">Caballero T</searchLink>; Department of Allergy, Hospital Universitario La Paz, Hospital La Paz Health Research Institute (IdiPAZ), biomedical Research Network on Rare Diseases (CIBERER, U754), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Cancian+M%22">Cancian M</searchLink>; Department of Systems Medicine, University Hospital of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Christiansen+S%22">Christiansen S</searchLink>; Division of Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Cohn+DM%22">Cohn DM</searchLink>; Amsterdam UMC, Cardiovascular Sciences, Department of Vascular Medicine, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Contreras+F%22">Contreras F</searchLink>; Allergy Service, National Institute of Pediatrics, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Craig+S%22">Craig S</searchLink>; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Isaic+C%22">Isaic C</searchLink>; HAE Junior Patient Organization, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Jindal+A%22">Jindal A</searchLink>; Pediatric Clinical Immunology and Rheumatology, Department of Pediatrics, Manipal Hospital, Bengaluru, India.<br /><searchLink fieldCode="AU" term="%22Katelaris+CH%22">Katelaris CH</searchLink>; Immunology & Allergy Unit Campbelltown Hospital and Western Sydney University, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Longhurst+HJ%22">Longhurst HJ</searchLink>; Department of Immunology, Auckland City Hospital and University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22MacGinnitie+A%22">MacGinnitie A</searchLink>; Division of Allergy, Asthma, and Immunology, Children's Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Peter+J%22">Peter J</searchLink>; Division of Allergy and Clinical Immunology, Groote Schuur Hospital, University of Cape Town, Rondebosch, South Africa.; Allergy and Immunology Unit, University of Cape Town Lung Institute, Rondebosch, South Africa.<br /><searchLink fieldCode="AU" term="%22Porebski+G%22">Porebski G</searchLink>; Department of Clinical and Environmental Allergology, Jagiellonian University Medical College, Krakow, Poland.<br /><searchLink fieldCode="AU" term="%22Reshef+A%22">Reshef A</searchLink>; Angioedema Research Center, Barzilai University Medical Center, Ashkelon, Israel.<br /><searchLink fieldCode="AU" term="%22Van+Nguyen+D%22">Van Nguyen D</searchLink>; Vinmec-VinUni Institute of Immunology, VinUniversity, Hanoi, Vietnam.; Center of Allergy and Clinical Immunology, Vinmec Times City, Vinmec Healthcare System, Hanoi, Vietnam.; College of Medicine, Penn State University, Hershey, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Zuraw+B%22">Zuraw B</searchLink>; Division of Allergy & Immunology, Department of Medicine, University of California San Diego, La Jolla, California, USA.; Medicine Service, Veterans Administration Healthcare, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Castaldo+AJ%22">Castaldo AJ</searchLink>; Hereditary Angioedema International, USA.<br /><searchLink fieldCode="AU" term="%22Boysen+HB%22">Boysen HB</searchLink>; Hereditary Angioedema International, USA.<br /><searchLink fieldCode="AU" term="%22Craig+T%22">Craig T</searchLink>; Department of Medicine, Pediatrics, OB/GYN MFM, and Biomedical Sciences, Penn State University, Hershey, Pennsylvania, USA.; Vin-Mec-VinUni Institute of Immunology, Vin University, Hanoi, Vietnam.
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