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Repeated 7-day exposure to ketamine induces anxiety-like behaviors and neuronal apoptosis in mice via DRD1-medicated inhibition of Akt/Gsk-3β phosphorylation.

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Title: Repeated 7-day exposure to ketamine induces anxiety-like behaviors and neuronal apoptosis in mice via DRD1-medicated inhibition of Akt/Gsk-3β phosphorylation.
Authors: Wei JY; Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, P.R. China., Lv P; School of Forensic Medicine, China Medical University, Shenyang, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China., Zhang J; Department of Pain, First Hospital of China Medical University, Shenyang, P.R. China., Hou XK; School of Forensic Medicine, China Medical University, Shenyang, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China., Li A; School of Forensic Medicine, China Medical University, Shenyang, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China., Zhang FT; School of Forensic Medicine, China Medical University, Shenyang, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China., Wang H; Department of Human Anatomy, School of Basic Medicine, Shenyang Medical College, Shenyang, P.R. China. wanghongbo@symc.edu.cn.; Liaoning Province Key Laboratory for Phenomics of Human Ethnic Specificity and Critical Illness, Shenyang, P.R. China. wanghongbo@symc.edu.cn., Lu Y; Key Laboratory of Health Ministry in Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China. luy1@sj-hospital.org., Wu X; School of Forensic Medicine, China Medical University, Shenyang, P.R. China. xwu@cmu.edu.cn.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China. xwu@cmu.edu.cn.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China. xwu@cmu.edu.cn., Yao J; School of Forensic Medicine, China Medical University, Shenyang, P.R. China. yaojun198717@163.com.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China. yaojun198717@163.com.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China. yaojun198717@163.com.
Source: Cell biology and toxicology [Cell Biol Toxicol] 2026 Jan 30; Vol. 42 (1), pp. 29. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 8506639 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6822 (Electronic) Linking ISSN: 07422091 NLM ISO Abbreviation: Cell Biol Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Repeated 7-day exposure to ketamine induces anxiety-like behaviors and neuronal apoptosis in mice via DRD1-medicated inhibition of Akt/Gsk-3β phosphorylation.
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  Data: <searchLink fieldCode="AU" term="%22Wei+JY%22">Wei JY</searchLink>; Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Lv+P%22">Lv P</searchLink>; School of Forensic Medicine, China Medical University, Shenyang, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Pain, First Hospital of China Medical University, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Hou+XK%22">Hou XK</searchLink>; School of Forensic Medicine, China Medical University, Shenyang, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+A%22">Li A</searchLink>; School of Forensic Medicine, China Medical University, Shenyang, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+FT%22">Zhang FT</searchLink>; School of Forensic Medicine, China Medical University, Shenyang, P.R. China.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Human Anatomy, School of Basic Medicine, Shenyang Medical College, Shenyang, P.R. China. wanghongbo@symc.edu.cn.; Liaoning Province Key Laboratory for Phenomics of Human Ethnic Specificity and Critical Illness, Shenyang, P.R. China. wanghongbo@symc.edu.cn.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Key Laboratory of Health Ministry in Congenital Malformation, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China. luy1@sj-hospital.org.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; School of Forensic Medicine, China Medical University, Shenyang, P.R. China. xwu@cmu.edu.cn.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China. xwu@cmu.edu.cn.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China. xwu@cmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yao+J%22">Yao J</searchLink>; School of Forensic Medicine, China Medical University, Shenyang, P.R. China. yaojun198717@163.com.; Key Laboratory of Forensic Bio-Evidence Sciences, Liaoning Province, Shenyang, P.R. China. yaojun198717@163.com.; China Medical University Center of Forensic Investigation, Shenyang, P.R. China. yaojun198717@163.com.
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  Data: <searchLink fieldCode="JN" term="%228506639%22">Cell biology and toxicology</searchLink> [Cell Biol Toxicol] 2026 Jan 30; Vol. 42 (1), pp. 29. <i>Date of Electronic Publication: </i>2026 Jan 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>8506639 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-6822 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2207422091%22">07422091 </searchLink><i>NLM ISO Abbreviation: </i>Cell Biol Toxicol <i>Subsets: </i>MEDLINE
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              Text: 2026 Jan 30
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