View in EDS

Ames concordance with the in vivo transgenic rodent (TGR) gene mutation assay for NDSRIs and relative in vivo TGR potency with nitrosamines with robust dose-response carcinogenicity data.

Saved in:
Bibliographic Details
Title: Ames concordance with the in vivo transgenic rodent (TGR) gene mutation assay for NDSRIs and relative in vivo TGR potency with nitrosamines with robust dose-response carcinogenicity data.
Authors: Jolly RA; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, IN, 46285, USA. Electronic address: jolly_robert_a@lilly.com., Trejo-Martin A; Gilead Sciences, Inc., Nonclinical Safety and Pathobiology, 333 Lakeside Drive, Foster City, CA, 94404, USA., Bercu JP; Gilead Sciences, Inc., Nonclinical Safety and Pathobiology, 333 Lakeside Drive, Foster City, CA, 94404, USA., Powley MW; Merck & Co. Inc., Nonclinical Drug Safety, Rahway, NJ, 07065, USA., Tennant RE; Lhasa Limited, Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK., Ponting DJ; Lhasa Limited, Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK., Nudelman R; Nudelman ChemTox Consulting Ltd.15 Miller St, Rehovot, 7628422, Israel., Sobol Z; Merck & Co. Inc., Nonclinical Drug Safety, Rahway, NJ, 07065, USA., Czich A; Sanofi, R&D Translational Medicine Preclinical Safety, D-69526, Frankfurt, DE, Germany., Johnson GE; Swansea University Medical School, Swansea University, Swansea, Wales, UK., Yang Y; AbbVie Inc., Global Preclinical Safety, North Chicago, IL, 60064, USA., Kobets T; New York Medical College, Department of Pathology, Microbiology and Immunology, Valhalla, NY, 10595, USA., White PA; Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, CA, USA., Minocherhomji S; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, IN, 46285, USA., Lynch AM; GSK, Genetic and Investigative Toxicology, Stevenage, Herts, SG1 2NY, UK., Zeller A; Pharmaceutical Sciences, pRED Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland., Ott GR; Teva Pharmaceuticals, West Chester, PA, 19380, USA., Escobar PA; Merck & Co. Inc., Nonclinical Drug Safety, Rahway, NJ, 07065, USA., Hobbs C; Inotiv, Rockville, MD, 20850, USA., Schuler M; Pfizer Research, Development, and Medical, Groton, CT, 06370, USA., Chen CL; Health and Environmental Sciences Institute, Washington, DC, 20005, USA., Puglisi R; Health and Environmental Sciences Institute, Washington, DC, 20005, USA.
Source: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2026 May; Vol. 167, pp. 106051. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214983 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0295 (Electronic) Linking ISSN: 02732300 NLM ISO Abbreviation: Regul Toxicol Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41621793
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Ames concordance with the in vivo transgenic rodent (TGR) gene mutation assay for NDSRIs and relative in vivo TGR potency with nitrosamines with robust dose-response carcinogenicity data.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Jolly+RA%22">Jolly RA</searchLink>; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, IN, 46285, USA. Electronic address: jolly_robert_a@lilly.com.<br /><searchLink fieldCode="AU" term="%22Trejo-Martin+A%22">Trejo-Martin A</searchLink>; Gilead Sciences, Inc., Nonclinical Safety and Pathobiology, 333 Lakeside Drive, Foster City, CA, 94404, USA.<br /><searchLink fieldCode="AU" term="%22Bercu+JP%22">Bercu JP</searchLink>; Gilead Sciences, Inc., Nonclinical Safety and Pathobiology, 333 Lakeside Drive, Foster City, CA, 94404, USA.<br /><searchLink fieldCode="AU" term="%22Powley+MW%22">Powley MW</searchLink>; Merck & Co. Inc., Nonclinical Drug Safety, Rahway, NJ, 07065, USA.<br /><searchLink fieldCode="AU" term="%22Tennant+RE%22">Tennant RE</searchLink>; Lhasa Limited, Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK.<br /><searchLink fieldCode="AU" term="%22Ponting+DJ%22">Ponting DJ</searchLink>; Lhasa Limited, Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK.<br /><searchLink fieldCode="AU" term="%22Nudelman+R%22">Nudelman R</searchLink>; Nudelman ChemTox Consulting Ltd.15 Miller St, Rehovot, 7628422, Israel.<br /><searchLink fieldCode="AU" term="%22Sobol+Z%22">Sobol Z</searchLink>; Merck & Co. Inc., Nonclinical Drug Safety, Rahway, NJ, 07065, USA.<br /><searchLink fieldCode="AU" term="%22Czich+A%22">Czich A</searchLink>; Sanofi, R&D Translational Medicine Preclinical Safety, D-69526, Frankfurt, DE, Germany.<br /><searchLink fieldCode="AU" term="%22Johnson+GE%22">Johnson GE</searchLink>; Swansea University Medical School, Swansea University, Swansea, Wales, UK.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; AbbVie Inc., Global Preclinical Safety, North Chicago, IL, 60064, USA.<br /><searchLink fieldCode="AU" term="%22Kobets+T%22">Kobets T</searchLink>; New York Medical College, Department of Pathology, Microbiology and Immunology, Valhalla, NY, 10595, USA.<br /><searchLink fieldCode="AU" term="%22White+PA%22">White PA</searchLink>; Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, CA, USA.<br /><searchLink fieldCode="AU" term="%22Minocherhomji+S%22">Minocherhomji S</searchLink>; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, IN, 46285, USA.<br /><searchLink fieldCode="AU" term="%22Lynch+AM%22">Lynch AM</searchLink>; GSK, Genetic and Investigative Toxicology, Stevenage, Herts, SG1 2NY, UK.<br /><searchLink fieldCode="AU" term="%22Zeller+A%22">Zeller A</searchLink>; Pharmaceutical Sciences, pRED Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ott+GR%22">Ott GR</searchLink>; Teva Pharmaceuticals, West Chester, PA, 19380, USA.<br /><searchLink fieldCode="AU" term="%22Escobar+PA%22">Escobar PA</searchLink>; Merck & Co. Inc., Nonclinical Drug Safety, Rahway, NJ, 07065, USA.<br /><searchLink fieldCode="AU" term="%22Hobbs+C%22">Hobbs C</searchLink>; Inotiv, Rockville, MD, 20850, USA.<br /><searchLink fieldCode="AU" term="%22Schuler+M%22">Schuler M</searchLink>; Pfizer Research, Development, and Medical, Groton, CT, 06370, USA.<br /><searchLink fieldCode="AU" term="%22Chen+CL%22">Chen CL</searchLink>; Health and Environmental Sciences Institute, Washington, DC, 20005, USA.<br /><searchLink fieldCode="AU" term="%22Puglisi+R%22">Puglisi R</searchLink>; Health and Environmental Sciences Institute, Washington, DC, 20005, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%228214983%22">Regulatory toxicology and pharmacology : RTP</searchLink> [Regul Toxicol Pharmacol] 2026 May; Vol. 167, pp. 106051. <i>Date of Electronic Publication: </i>2026 Jan 30.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8214983 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1096-0295 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202732300%22">02732300 </searchLink><i>NLM ISO Abbreviation: </i>Regul Toxicol Pharmacol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41621793
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.yrtph.2026.106051
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 106051
    Titles:
      – TitleFull: Ames concordance with the in vivo transgenic rodent (TGR) gene mutation assay for NDSRIs and relative in vivo TGR potency with nitrosamines with robust dose-response carcinogenicity data.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Jolly RA
      – PersonEntity:
          Name:
            NameFull: Trejo-Martin A
      – PersonEntity:
          Name:
            NameFull: Bercu JP
      – PersonEntity:
          Name:
            NameFull: Powley MW
      – PersonEntity:
          Name:
            NameFull: Tennant RE
      – PersonEntity:
          Name:
            NameFull: Ponting DJ
      – PersonEntity:
          Name:
            NameFull: Nudelman R
      – PersonEntity:
          Name:
            NameFull: Sobol Z
      – PersonEntity:
          Name:
            NameFull: Czich A
      – PersonEntity:
          Name:
            NameFull: Johnson GE
      – PersonEntity:
          Name:
            NameFull: Yang Y
      – PersonEntity:
          Name:
            NameFull: Kobets T
      – PersonEntity:
          Name:
            NameFull: White PA
      – PersonEntity:
          Name:
            NameFull: Minocherhomji S
      – PersonEntity:
          Name:
            NameFull: Lynch AM
      – PersonEntity:
          Name:
            NameFull: Zeller A
      – PersonEntity:
          Name:
            NameFull: Ott GR
      – PersonEntity:
          Name:
            NameFull: Escobar PA
      – PersonEntity:
          Name:
            NameFull: Hobbs C
      – PersonEntity:
          Name:
            NameFull: Schuler M
      – PersonEntity:
          Name:
            NameFull: Chen CL
      – PersonEntity:
          Name:
            NameFull: Puglisi R
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2026 May
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1096-0295
          Numbering:
            – Type: volume
              Value: 167
          Titles:
            – TitleFull: Regulatory toxicology and pharmacology : RTP
              Type: main
ResultId 1