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Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling.

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Title: Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling.
Authors: Krishna A; The Roslin Institute, University of Edinburgh, Edinburgh, UK., Meynert A; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Dolt KS; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands., Kelder M; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Mesropian A; Liver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain., Ewing A; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Brouwers C; Transgenic Facility Leiden, Central Animal Facility, Leiden University Medical Centre, Leiden, The Netherlands., Claassens JW; Transgenic Facility Leiden, Central Animal Facility, Leiden University Medical Centre, Leiden, The Netherlands., Linssen MM; Transgenic Facility Leiden, Central Animal Facility, Leiden University Medical Centre, Leiden, The Netherlands., Sheraz S; The Roslin Institute, University of Edinburgh, Edinburgh, UK., Taylor GC; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Gautier P; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Ferrer-Vaquer A; Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Grimes G; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Becher H; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Silk R; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Gris-Oliver A; Liver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain., Pinyol R; Liver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain., Semple CA; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Kendall TJ; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK., Bird TG; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Institute, Glasgow, UK.; Cancer Research Scotland Centre, Edinburgh, UK.; Cancer Research Scotland Centre, Glasgow, UK., Hadjantonakis AK; Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Marsh JA; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Llovet JM; Liver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain.; Mount Sinai Liver Cancer Program, Divisions of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain., Hohenstein P; The Roslin Institute, University of Edinburgh, Edinburgh, UK. P.Hohenstein@lumc.nl.; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands. P.Hohenstein@lumc.nl.; Transgenic Facility Leiden, Central Animal Facility, Leiden University Medical Centre, Leiden, The Netherlands. P.Hohenstein@lumc.nl., Wood AJ; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. Andrew.j.wood@ed.ac.uk., Ozdemir DD; The Roslin Institute, University of Edinburgh, Edinburgh, UK. Deozdemir@ku.edu.tr.; Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey. Deozdemir@ku.edu.tr.; Koç University School of Medicine, Istanbul, Turkey. Deozdemir@ku.edu.tr.
Source: Nature genetics [Nat Genet] 2026 Feb; Vol. 58 (2), pp. 366-375. Date of Electronic Publication: 2026 Feb 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling.
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  Data: <searchLink fieldCode="AU" term="%22Krishna+A%22">Krishna A</searchLink>; The Roslin Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Meynert+A%22">Meynert A</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Dolt+KS%22">Dolt KS</searchLink>; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kelder+M%22">Kelder M</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Mesropian+A%22">Mesropian A</searchLink>; Liver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ewing+A%22">Ewing A</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Brouwers+C%22">Brouwers C</searchLink>; Transgenic Facility Leiden, Central Animal Facility, Leiden University Medical Centre, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Claassens+JW%22">Claassens JW</searchLink>; Transgenic Facility Leiden, Central Animal Facility, Leiden University Medical Centre, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Linssen+MM%22">Linssen MM</searchLink>; Transgenic Facility Leiden, Central Animal Facility, Leiden University Medical Centre, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sheraz+S%22">Sheraz S</searchLink>; The Roslin Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Taylor+GC%22">Taylor GC</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Gautier+P%22">Gautier P</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Ferrer-Vaquer+A%22">Ferrer-Vaquer A</searchLink>; Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Grimes+G%22">Grimes G</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Becher+H%22">Becher H</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Silk+R%22">Silk R</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Gris-Oliver+A%22">Gris-Oliver A</searchLink>; Liver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pinyol+R%22">Pinyol R</searchLink>; Liver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Semple+CA%22">Semple CA</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Kendall+TJ%22">Kendall TJ</searchLink>; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Bird+TG%22">Bird TG</searchLink>; Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Scotland Institute, Glasgow, UK.; Cancer Research Scotland Centre, Edinburgh, UK.; Cancer Research Scotland Centre, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Hadjantonakis+AK%22">Hadjantonakis AK</searchLink>; Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Marsh+JA%22">Marsh JA</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Llovet+JM%22">Llovet JM</searchLink>; Liver Cancer Translational Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain.; Mount Sinai Liver Cancer Program, Divisions of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Hohenstein+P%22">Hohenstein P</searchLink>; The Roslin Institute, University of Edinburgh, Edinburgh, UK. P.Hohenstein@lumc.nl.; Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands. P.Hohenstein@lumc.nl.; Transgenic Facility Leiden, Central Animal Facility, Leiden University Medical Centre, Leiden, The Netherlands. P.Hohenstein@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Wood+AJ%22">Wood AJ</searchLink>; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. Andrew.j.wood@ed.ac.uk.<br /><searchLink fieldCode="AU" term="%22Ozdemir+DD%22">Ozdemir DD</searchLink>; The Roslin Institute, University of Edinburgh, Edinburgh, UK. Deozdemir@ku.edu.tr.; Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey. Deozdemir@ku.edu.tr.; Koç University School of Medicine, Istanbul, Turkey. Deozdemir@ku.edu.tr.
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