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APP-mediated intracellular signaling rescues sleep impairment and blood-brain barrier leakage in Alzheimer's disease mouse model.

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Title: APP-mediated intracellular signaling rescues sleep impairment and blood-brain barrier leakage in Alzheimer's disease mouse model.
Authors: Puech C; Department of Pediatrics, School of Medicine, University of Missouri, Columbia, Missouri, USA.; Clémentine Puech, Group of Precision Medicine in Chronic Diseases. Hospital Nacional de Parapléjicos. IDISCAM, Toledo, Spain., Sadanand A; Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA., Coleman N; Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA., Ikhane M; Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA., Badran M; Department of Pediatrics, School of Medicine, University of Missouri, Columbia, Missouri, USA.; Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri, USA., Wang R; Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA., Gozal D; Department of Pediatrics, School of Medicine, University of Missouri, Columbia, Missouri, USA.; Departments of Pediatrics and Biomedical Sciences and Office of the Dean, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA., Parent AT; Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Feb; Vol. 22 (2), pp. e71134.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: APP-mediated intracellular signaling rescues sleep impairment and blood-brain barrier leakage in Alzheimer's disease mouse model.
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  Data: <searchLink fieldCode="AU" term="%22Puech+C%22">Puech C</searchLink>; Department of Pediatrics, School of Medicine, University of Missouri, Columbia, Missouri, USA.; Clémentine Puech, Group of Precision Medicine in Chronic Diseases. Hospital Nacional de Parapléjicos. IDISCAM, Toledo, Spain.<br /><searchLink fieldCode="AU" term="%22Sadanand+A%22">Sadanand A</searchLink>; Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Coleman+N%22">Coleman N</searchLink>; Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Ikhane+M%22">Ikhane M</searchLink>; Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Badran+M%22">Badran M</searchLink>; Department of Pediatrics, School of Medicine, University of Missouri, Columbia, Missouri, USA.; Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Gozal+D%22">Gozal D</searchLink>; Department of Pediatrics, School of Medicine, University of Missouri, Columbia, Missouri, USA.; Departments of Pediatrics and Biomedical Sciences and Office of the Dean, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Parent+AT%22">Parent AT</searchLink>; Department of Molecular Medicine, University of South Florida, Tampa, Florida, USA.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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        Value: 10.1002/alz.71134
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      – TitleFull: APP-mediated intracellular signaling rescues sleep impairment and blood-brain barrier leakage in Alzheimer's disease mouse model.
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              Text: 2026 Feb
              Type: published
              Y: 2026
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