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Kras G12C- and G12D-driven lung cancers differ in oncogenic potency, immunogenicity, and relapse after Kras inhibition in mouse models.

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Title: Kras G12C- and G12D-driven lung cancers differ in oncogenic potency, immunogenicity, and relapse after Kras inhibition in mouse models.
Authors: Huang HC; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Harold C. Simmons Comprehensive Cancer Center, Dallas, TX 75390, USA., Deng Q; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Harold C. Simmons Comprehensive Cancer Center, Dallas, TX 75390, USA., Guo L; Quantitative Biomedical Research Center, Department of Population & Data Sciences, Dallas, TX 75390, USA., Gorria T; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Pecci F; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Yang D; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Harold C. Simmons Comprehensive Cancer Center, Dallas, TX 75390, USA., Rodig S; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA., De Las Casas L; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Hallin J; Mirati Pharmaceuticals (a Bristol Myers Squibb company), San Diego, CA 92121, USA., Christensen JG; Mirati Pharmaceuticals (a Bristol Myers Squibb company), San Diego, CA 92121, USA., Awad MM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Xu L; Harold C. Simmons Comprehensive Cancer Center, Dallas, TX 75390, USA.; Quantitative Biomedical Research Center, Department of Population & Data Sciences, Dallas, TX 75390, USA.; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390, USA., Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Akbay EA; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Harold C. Simmons Comprehensive Cancer Center, Dallas, TX 75390, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Feb 04; Vol. 18 (835), pp. eadq6647. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Kras G12C- and G12D-driven lung cancers differ in oncogenic potency, immunogenicity, and relapse after Kras inhibition in mouse models.
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