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Sine oculis homeobox 1 drives endothelial dysfunction in preclinical pulmonary arterial hypertension.

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Title: Sine oculis homeobox 1 drives endothelial dysfunction in preclinical pulmonary arterial hypertension.
Authors: Liu T; Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.; Clinical Research Institute, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang 310014, China., Zhou W; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-Based Medical Materials, Wuhan, Hubei 430071, China., Fang C; Department of Lung Transplantation, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China., Liang Y; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Zhao Z; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Cai A; Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China., Peng X; Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang 310006, China., Ye X; Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang 310006, China., Bai M; Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang 310006, China., Hu X; Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.; Zhejiang Provincial Clinical Research Center for Malignant Tumor, Hangzhou, Zhejiang 310014, China.; Zhejiang Key Laboratory of Precision Medicine Research on Head & Neck Cancer, Hangzhou, Zhejiang 310014, China., Lin N; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang 310014, China., Zou X; Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.; Zhejiang Provincial Clinical Research Center for Malignant Tumor, Hangzhou, Zhejiang 310014, China.; Zhejiang Key Laboratory of Precision Medicine Research on Head & Neck Cancer, Hangzhou, Zhejiang 310014, China., Huang P; Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.; Zhejiang Provincial Clinical Research Center for Malignant Tumor, Hangzhou, Zhejiang 310014, China.; Zhejiang Key Laboratory of Precision Medicine Research on Head & Neck Cancer, Hangzhou, Zhejiang 310014, China.
Source: Science translational medicine [Sci Transl Med] 2026 Feb 04; Vol. 18 (835), pp. eadu6425. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sine oculis homeobox 1 drives endothelial dysfunction in preclinical pulmonary arterial hypertension.
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  Data: <searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.; Clinical Research Institute, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang 310014, China.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natural Polymer Biological Liver, Hubei Engineering Center of Natural Polymer-Based Medical Materials, Wuhan, Hubei 430071, China.<br /><searchLink fieldCode="AU" term="%22Fang+C%22">Fang C</searchLink>; Department of Lung Transplantation, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Z%22">Zhao Z</searchLink>; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.<br /><searchLink fieldCode="AU" term="%22Cai+A%22">Cai A</searchLink>; Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.<br /><searchLink fieldCode="AU" term="%22Peng+X%22">Peng X</searchLink>; Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang 310006, China.<br /><searchLink fieldCode="AU" term="%22Ye+X%22">Ye X</searchLink>; Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang 310006, China.<br /><searchLink fieldCode="AU" term="%22Bai+M%22">Bai M</searchLink>; Department of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang 310006, China.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.; Zhejiang Provincial Clinical Research Center for Malignant Tumor, Hangzhou, Zhejiang 310014, China.; Zhejiang Key Laboratory of Precision Medicine Research on Head & Neck Cancer, Hangzhou, Zhejiang 310014, China.<br /><searchLink fieldCode="AU" term="%22Lin+N%22">Lin N</searchLink>; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang 310014, China.<br /><searchLink fieldCode="AU" term="%22Zou+X%22">Zou X</searchLink>; Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.; Zhejiang Provincial Clinical Research Center for Malignant Tumor, Hangzhou, Zhejiang 310014, China.; Zhejiang Key Laboratory of Precision Medicine Research on Head & Neck Cancer, Hangzhou, Zhejiang 310014, China.<br /><searchLink fieldCode="AU" term="%22Huang+P%22">Huang P</searchLink>; Center for Clinical Pharmacy, Cancer Center, Department of Pharmacy, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.; Zhejiang Provincial Clinical Research Center for Malignant Tumor, Hangzhou, Zhejiang 310014, China.; Zhejiang Key Laboratory of Precision Medicine Research on Head & Neck Cancer, Hangzhou, Zhejiang 310014, China.
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        Value: 10.1126/scitranslmed.adu6425
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