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Synergistic targeting of the ARID2-MYC axis by pomalidomide and panobinostat overcomes intrinsic IMiD resistance in multiple myeloma.

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Title: Synergistic targeting of the ARID2-MYC axis by pomalidomide and panobinostat overcomes intrinsic IMiD resistance in multiple myeloma.
Authors: Yamamoto J; School of Life Science and Technology, Institute of Science Tokyo, Yokohama, 226-8501, Japan. yamamoto.j.0c42@m.isct.ac.jp., Asatsuma-Okumura T; Department of Cell Biology, Institute of Advanced Medical Sciences, Graduate School of Medicine, Nippon Medical School, Bunkyo, 113-8602, Japan., Ito T; Institute of Medical Science, Tokyo Medical University, Shinjuku, 160-8402, Japan., Iwai Y; Department of Cell Biology, Institute of Advanced Medical Sciences, Graduate School of Medicine, Nippon Medical School, Bunkyo, 113-8602, Japan., Handa H; Department of Molecular Pharmacology, Center for Future Medical Research, Institute of Medical Science, Tokyo Medical University, Shinjuku, 160-8402, Japan., Yamaguchi Y; School of Life Science and Technology, Institute of Science Tokyo, Yokohama, 226-8501, Japan.
Source: Scientific reports [Sci Rep] 2026 Feb 05; Vol. 16 (1). Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Yamamoto+J%22">Yamamoto J</searchLink>; School of Life Science and Technology, Institute of Science Tokyo, Yokohama, 226-8501, Japan. yamamoto.j.0c42@m.isct.ac.jp.<br /><searchLink fieldCode="AU" term="%22Asatsuma-Okumura+T%22">Asatsuma-Okumura T</searchLink>; Department of Cell Biology, Institute of Advanced Medical Sciences, Graduate School of Medicine, Nippon Medical School, Bunkyo, 113-8602, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+T%22">Ito T</searchLink>; Institute of Medical Science, Tokyo Medical University, Shinjuku, 160-8402, Japan.<br /><searchLink fieldCode="AU" term="%22Iwai+Y%22">Iwai Y</searchLink>; Department of Cell Biology, Institute of Advanced Medical Sciences, Graduate School of Medicine, Nippon Medical School, Bunkyo, 113-8602, Japan.<br /><searchLink fieldCode="AU" term="%22Handa+H%22">Handa H</searchLink>; Department of Molecular Pharmacology, Center for Future Medical Research, Institute of Medical Science, Tokyo Medical University, Shinjuku, 160-8402, Japan.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+Y%22">Yamaguchi Y</searchLink>; School of Life Science and Technology, Institute of Science Tokyo, Yokohama, 226-8501, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Feb 05; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 Feb 05.
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        Value: 10.1038/s41598-026-37740-3
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              Text: 2026 Feb 05
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