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Chemical inhibition of INO1 reduces phytic acid in rice and wheat grains for enhanced micronutrient bioavailability.

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Title: Chemical inhibition of INO1 reduces phytic acid in rice and wheat grains for enhanced micronutrient bioavailability.
Authors: Akabane T; Graduate School of Life Sciences, Toyo University, Asaka, Japan.; HPC- and AI-driven Drug Development Platform Division, RIKEN Center for Computational Science, Yokohama, Japan., Kamino S; CRYO SHIP Incorporated, Saitama, Japan., Okamura T; Graduate School of Life Sciences, Toyo University, Asaka, Japan., Sugaya A; Faculty of Life Sciences, Toyo University, Asaka, Japan., Nakamura M; Faculty of Life Sciences, Toyo University, Asaka, Japan., Ikeda K; HPC- and AI-driven Drug Development Platform Division, RIKEN Center for Computational Science, Yokohama, Japan.; Division of Physics for Life Functions, Keio University Faculty of Pharmacy, Tokyo, Japan., Yonezawa T; Division of Physics for Life Functions, Keio University Faculty of Pharmacy, Tokyo, Japan., Fukushima A; Graduate School of Life Sciences, Toyo University, Asaka, Japan., Kojima S; Graduate School of Life Sciences, Toyo University, Asaka, Japan., Aoki Y; Faculty of Life Sciences, Toyo University, Asaka, Japan., Chujo S; Graduate School of Food and Nutritional Sciences, Toyo University, Asaka, Japan., Yamauchi Y; Graduate School of Life Sciences, Toyo University, Asaka, Japan., Shibusawa R; Graduate School of Life Sciences, Toyo University, Asaka, Japan., Ishimaru K; Institute of Crop Science, National Agriculture and Food Research Organization, Tsukuba, Japan., Nagasaka S; Graduate School of Life Sciences, Toyo University, Asaka, Japan.; Faculty of Life Sciences, Toyo University, Asaka, Japan., Katoh E; Graduate School of Food and Nutritional Sciences, Toyo University, Asaka, Japan. katoh@toyo.jp., Hirotsu N; Graduate School of Life Sciences, Toyo University, Asaka, Japan. hirotsu@toyo.jp.; Faculty of Life Sciences, Toyo University, Asaka, Japan. hirotsu@toyo.jp.
Source: Nature food [Nat Food] 2026 Feb; Vol. 7 (2), pp. 163-173. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761102 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1355 (Electronic) Linking ISSN: 26621355 NLM ISO Abbreviation: Nat Food Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chemical inhibition of INO1 reduces phytic acid in rice and wheat grains for enhanced micronutrient bioavailability.
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  Data: <searchLink fieldCode="AU" term="%22Akabane+T%22">Akabane T</searchLink>; Graduate School of Life Sciences, Toyo University, Asaka, Japan.; HPC- and AI-driven Drug Development Platform Division, RIKEN Center for Computational Science, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Kamino+S%22">Kamino S</searchLink>; CRYO SHIP Incorporated, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Okamura+T%22">Okamura T</searchLink>; Graduate School of Life Sciences, Toyo University, Asaka, Japan.<br /><searchLink fieldCode="AU" term="%22Sugaya+A%22">Sugaya A</searchLink>; Faculty of Life Sciences, Toyo University, Asaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+M%22">Nakamura M</searchLink>; Faculty of Life Sciences, Toyo University, Asaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ikeda+K%22">Ikeda K</searchLink>; HPC- and AI-driven Drug Development Platform Division, RIKEN Center for Computational Science, Yokohama, Japan.; Division of Physics for Life Functions, Keio University Faculty of Pharmacy, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yonezawa+T%22">Yonezawa T</searchLink>; Division of Physics for Life Functions, Keio University Faculty of Pharmacy, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Fukushima+A%22">Fukushima A</searchLink>; Graduate School of Life Sciences, Toyo University, Asaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kojima+S%22">Kojima S</searchLink>; Graduate School of Life Sciences, Toyo University, Asaka, Japan.<br /><searchLink fieldCode="AU" term="%22Aoki+Y%22">Aoki Y</searchLink>; Faculty of Life Sciences, Toyo University, Asaka, Japan.<br /><searchLink fieldCode="AU" term="%22Chujo+S%22">Chujo S</searchLink>; Graduate School of Food and Nutritional Sciences, Toyo University, Asaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yamauchi+Y%22">Yamauchi Y</searchLink>; Graduate School of Life Sciences, Toyo University, Asaka, Japan.<br /><searchLink fieldCode="AU" term="%22Shibusawa+R%22">Shibusawa R</searchLink>; Graduate School of Life Sciences, Toyo University, Asaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ishimaru+K%22">Ishimaru K</searchLink>; Institute of Crop Science, National Agriculture and Food Research Organization, Tsukuba, Japan.<br /><searchLink fieldCode="AU" term="%22Nagasaka+S%22">Nagasaka S</searchLink>; Graduate School of Life Sciences, Toyo University, Asaka, Japan.; Faculty of Life Sciences, Toyo University, Asaka, Japan.<br /><searchLink fieldCode="AU" term="%22Katoh+E%22">Katoh E</searchLink>; Graduate School of Food and Nutritional Sciences, Toyo University, Asaka, Japan. katoh@toyo.jp.<br /><searchLink fieldCode="AU" term="%22Hirotsu+N%22">Hirotsu N</searchLink>; Graduate School of Life Sciences, Toyo University, Asaka, Japan. hirotsu@toyo.jp.; Faculty of Life Sciences, Toyo University, Asaka, Japan. hirotsu@toyo.jp.
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