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Homogentisic Acid Disrupts the Blood-Brain Barrier and Promotes Aβ Aggregation in Alzheimer's Disease.

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Title: Homogentisic Acid Disrupts the Blood-Brain Barrier and Promotes Aβ Aggregation in Alzheimer's Disease.
Authors: Liu X; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Xu QQ; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Zhang YB; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Yuan SY; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Huang WL; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Pi MS; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Xiong Q; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Gui YR; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Deng SC; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Wan L; Renmin Hospital of Huangpi District of Jianghan University, Wuhan, 430399, China., Xiao YF; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China., Wang XC; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China., Shu XJ; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China. xijishu@jhun.edu.cn.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. xijishu@jhun.edu.cn.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China. xijishu@jhun.edu.cn., Xia YY; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China. xyy@jhun.edu.cn.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. xyy@jhun.edu.cn.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China. xyy@jhun.edu.cn.
Source: Current medical science [Curr Med Sci] 2026 Feb; Vol. 46 (1), pp. 229-243. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: Huazhong University of Science and Technology Country of Publication: China NLM ID: 101729993 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2523-899X (Electronic) Linking ISSN: 2523899X NLM ISO Abbreviation: Curr Med Sci Subsets: MEDLINE
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  Data: Homogentisic Acid Disrupts the Blood-Brain Barrier and Promotes Aβ Aggregation in Alzheimer's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.<br /><searchLink fieldCode="AU" term="%22Xu+QQ%22">Xu QQ</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YB%22">Zhang YB</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.<br /><searchLink fieldCode="AU" term="%22Yuan+SY%22">Yuan SY</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.<br /><searchLink fieldCode="AU" term="%22Huang+WL%22">Huang WL</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.<br /><searchLink fieldCode="AU" term="%22Pi+MS%22">Pi MS</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.<br /><searchLink fieldCode="AU" term="%22Xiong+Q%22">Xiong Q</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.<br /><searchLink fieldCode="AU" term="%22Gui+YR%22">Gui YR</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.<br /><searchLink fieldCode="AU" term="%22Deng+SC%22">Deng SC</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.<br /><searchLink fieldCode="AU" term="%22Wan+L%22">Wan L</searchLink>; Renmin Hospital of Huangpi District of Jianghan University, Wuhan, 430399, China.<br /><searchLink fieldCode="AU" term="%22Xiao+YF%22">Xiao YF</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China.<br /><searchLink fieldCode="AU" term="%22Wang+XC%22">Wang XC</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China.<br /><searchLink fieldCode="AU" term="%22Shu+XJ%22">Shu XJ</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China. xijishu@jhun.edu.cn.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. xijishu@jhun.edu.cn.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China. xijishu@jhun.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xia+YY%22">Xia YY</searchLink>; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China. xyy@jhun.edu.cn.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. xyy@jhun.edu.cn.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China. xyy@jhun.edu.cn.
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        Value: 10.1007/s11596-026-00165-0
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        Text: English
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      – TitleFull: Homogentisic Acid Disrupts the Blood-Brain Barrier and Promotes Aβ Aggregation in Alzheimer's Disease.
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              Text: 2026 Feb
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