Homogentisic Acid Disrupts the Blood-Brain Barrier and Promotes Aβ Aggregation in Alzheimer's Disease.

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Title: Homogentisic Acid Disrupts the Blood-Brain Barrier and Promotes Aβ Aggregation in Alzheimer's Disease.
Authors: Liu X; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Xu QQ; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Zhang YB; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Yuan SY; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Huang WL; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Pi MS; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Xiong Q; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Gui YR; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Deng SC; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Wan L; Renmin Hospital of Huangpi District of Jianghan University, Wuhan, 430399, China., Xiao YF; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China., Wang XC; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China., Shu XJ; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China. xijishu@jhun.edu.cn.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. xijishu@jhun.edu.cn.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China. xijishu@jhun.edu.cn., Xia YY; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China. xyy@jhun.edu.cn.; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. xyy@jhun.edu.cn.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, 430056, China. xyy@jhun.edu.cn.
Source: Current medical science [Curr Med Sci] 2026 Feb; Vol. 46 (1), pp. 229-243. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: Huazhong University of Science and Technology Country of Publication: China NLM ID: 101729993 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2523-899X (Electronic) Linking ISSN: 2523899X NLM ISO Abbreviation: Curr Med Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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