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A generalizable foundation model for analysis of human brain MRI.

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Title: A generalizable foundation model for analysis of human brain MRI.
Authors: Tak D; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Garomsa BA; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Zapaishchykova A; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Chaunzwa TL; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Climent Pardo JC; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ye Z; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Zielke J; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ravipati Y; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Pai S; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Vajapeyam S; Boston Children's Hospital, Boston, MA, USA., Mahootiha M; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Parker M; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pike LRG; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Smith C; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Familiar AM; University of Pennsylvania, Philadelphia, PA, USA., Liu KX; Boston Children's Hospital, Boston, MA, USA., Prabhu S; Boston Children's Hospital, Boston, MA, USA., Arnaout O; Brigham and Women's Hospital, Neurosciences Center, Boston, MA, USA., Bandopadhayay P; Boston Children's Hospital, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Nabavizadeh A; University of Pennsylvania, Philadelphia, PA, USA.; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Mueller S; Department of Neurology, Neurosurgery and Pediatrics, University of California, San Francisco, CA, USA., Aerts HJ; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Radiology and Nuclear Medicine, CARIM and GROW, Maastricht University, Maastricht, The Netherlands., Huang RY; Boston Children's Hospital, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Poussaint TY; Boston Children's Hospital, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Kann BH; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA. bkann@bwh.harvard.edu.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. bkann@bwh.harvard.edu.; Dana-Farber Cancer Institute, Boston, MA, USA. bkann@bwh.harvard.edu.
Source: Nature neuroscience [Nat Neurosci] 2026 Apr; Vol. 29 (4), pp. 945-956. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A generalizable foundation model for analysis of human brain MRI.
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  Data: <searchLink fieldCode="AU" term="%22Tak+D%22">Tak D</searchLink>; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Garomsa+BA%22">Garomsa BA</searchLink>; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zapaishchykova+A%22">Zapaishchykova A</searchLink>; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chaunzwa+TL%22">Chaunzwa TL</searchLink>; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Climent+Pardo+JC%22">Climent Pardo JC</searchLink>; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ye+Z%22">Ye Z</searchLink>; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zielke+J%22">Zielke J</searchLink>; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ravipati+Y%22">Ravipati Y</searchLink>; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pai+S%22">Pai S</searchLink>; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vajapeyam+S%22">Vajapeyam S</searchLink>; Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mahootiha+M%22">Mahootiha M</searchLink>; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Parker+M%22">Parker M</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pike+LRG%22">Pike LRG</searchLink>; Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Smith+C%22">Smith C</searchLink>; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Familiar+AM%22">Familiar AM</searchLink>; University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+KX%22">Liu KX</searchLink>; Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Prabhu+S%22">Prabhu S</searchLink>; Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Arnaout+O%22">Arnaout O</searchLink>; Brigham and Women's Hospital, Neurosciences Center, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bandopadhayay+P%22">Bandopadhayay P</searchLink>; Boston Children's Hospital, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nabavizadeh+A%22">Nabavizadeh A</searchLink>; University of Pennsylvania, Philadelphia, PA, USA.; Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mueller+S%22">Mueller S</searchLink>; Department of Neurology, Neurosurgery and Pediatrics, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Aerts+HJ%22">Aerts HJ</searchLink>; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Radiology and Nuclear Medicine, CARIM and GROW, Maastricht University, Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Huang+RY%22">Huang RY</searchLink>; Boston Children's Hospital, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Poussaint+TY%22">Poussaint TY</searchLink>; Boston Children's Hospital, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kann+BH%22">Kann BH</searchLink>; Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Boston, MA, USA. bkann@bwh.harvard.edu.; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. bkann@bwh.harvard.edu.; Dana-Farber Cancer Institute, Boston, MA, USA. bkann@bwh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%229809671%22">Nature neuroscience</searchLink> [Nat Neurosci] 2026 Apr; Vol. 29 (4), pp. 945-956. <i>Date of Electronic Publication: </i>2026 Feb 05.
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