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Unrestrained fatty acid oxidation triggers heart failure in mice via cardiolipin loss and mitochondrial dysfunction.

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Title: Unrestrained fatty acid oxidation triggers heart failure in mice via cardiolipin loss and mitochondrial dysfunction.
Authors: Kim CW; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046., Vale G; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046., Fu X; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046., McDonald J; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046., Dai C; Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046., Li C; Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046., Wang ZV; Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010., Sharma G; Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046., Khemtong C; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046., Malloy C; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046., Deja S; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046., Burgess SC; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046., Mitsche M; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046., Horton JD; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 12. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Unrestrained fatty acid oxidation triggers heart failure in mice via cardiolipin loss and mitochondrial dysfunction.
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  Data: <searchLink fieldCode="AU" term="%22Kim+CW%22">Kim CW</searchLink>; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.<br /><searchLink fieldCode="AU" term="%22Vale+G%22">Vale G</searchLink>; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.<br /><searchLink fieldCode="AU" term="%22Fu+X%22">Fu X</searchLink>; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.<br /><searchLink fieldCode="AU" term="%22McDonald+J%22">McDonald J</searchLink>; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.<br /><searchLink fieldCode="AU" term="%22Dai+C%22">Dai C</searchLink>; Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.<br /><searchLink fieldCode="AU" term="%22Wang+ZV%22">Wang ZV</searchLink>; Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Department of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010.<br /><searchLink fieldCode="AU" term="%22Sharma+G%22">Sharma G</searchLink>; Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.<br /><searchLink fieldCode="AU" term="%22Khemtong+C%22">Khemtong C</searchLink>; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.<br /><searchLink fieldCode="AU" term="%22Malloy+C%22">Malloy C</searchLink>; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.<br /><searchLink fieldCode="AU" term="%22Deja+S%22">Deja S</searchLink>; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.<br /><searchLink fieldCode="AU" term="%22Burgess+SC%22">Burgess SC</searchLink>; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.<br /><searchLink fieldCode="AU" term="%22Mitsche+M%22">Mitsche M</searchLink>; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.<br /><searchLink fieldCode="AU" term="%22Horton+JD%22">Horton JD</searchLink>; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046.
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