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Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation.

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Title: Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation.
Authors: Fisher IJ; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA., Senarath K; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA., Outlaw K; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA., Muralidharan K; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.; Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Garland-Kuntz EE; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA., Van Camp M; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA., Komay T; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA., Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan., Kostenis E; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany., Lambert NA; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA., Lyon AM; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 14. Date of Electronic Publication: 2026 Jan 14.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Fisher+IJ%22">Fisher IJ</searchLink>; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.<br /><searchLink fieldCode="AU" term="%22Senarath+K%22">Senarath K</searchLink>; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Outlaw+K%22">Outlaw K</searchLink>; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.<br /><searchLink fieldCode="AU" term="%22Muralidharan+K%22">Muralidharan K</searchLink>; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.; Center for Clinical and Translational Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Garland-Kuntz+EE%22">Garland-Kuntz EE</searchLink>; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.<br /><searchLink fieldCode="AU" term="%22Van+Camp+M%22">Van Camp M</searchLink>; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.<br /><searchLink fieldCode="AU" term="%22Komay+T%22">Komay T</searchLink>; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.<br /><searchLink fieldCode="AU" term="%22Inoue+A%22">Inoue A</searchLink>; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.; Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, 606-8501, Japan.<br /><searchLink fieldCode="AU" term="%22Kostenis+E%22">Kostenis E</searchLink>; Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Lambert+NA%22">Lambert NA</searchLink>; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Lyon+AM%22">Lyon AM</searchLink>; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA.; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
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              Text: 2026 Jan 14
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