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Suppression of interferon signaling via small-molecule modulation of TFAM.

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Title: Suppression of interferon signaling via small-molecule modulation of TFAM.
Authors: Sideris D; Astellas Pharmaceuticals Inc, Oncology Research, Cancer Biology, Cambridge, United States., Lee H; Astellas Pharmaceuticals Inc, Oncology Research, Cancer Biology, Cambridge, United States., Olson L; Astellas Pharmaceuticals Inc, Oncology Research, Cancer Biology, Cambridge, United States., Nallaparaju K; Astellas Pharmaceuticals Inc, Oncology Research, Cancer Biology, Cambridge, United States., Okuyama K; Astellas Pharmaceuticals Inc, Oncology Medicinal Chemistry, Cambridge, United States., Ciavarri J; Astellas Pharmaceuticals Inc, Oncology Medicinal Chemistry, Cambridge, United States., Lafyatis R; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, United States., Larsen M; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, United States., Lin B; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, United States., Alfaras I; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, United States., Kennerdell J; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, United States., Finkel T; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, United States.; Department of Medicine, Division of Cardiology, University of Pittsburgh, Pittsburgh, United States.; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States., Liu Y; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, United States.; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States.; Generian Pharmaceuticals, Pittsburgh, United States., Chen B; Aging Institute, University of Pittsburgh/UPMC, Pittsburgh, United States.; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, United States.; Generian Pharmaceuticals, Pittsburgh, United States.; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, United States., Lyu L; Astellas Pharmaceuticals Inc, Oncology Research, Cancer Biology, Cambridge, United States.
Source: ELife [Elife] 2026 Feb 06; Vol. 14. Date of Electronic Publication: 2026 Feb 06.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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