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Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.

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Title: Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.
Authors: Broderick JP; Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA. Electronic address: broderjp@ucmail.uc.edu., Naidech AM; Department of Neurology, Northwestern Medicine, Chicago, IL, USA., Elm JJ; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA., Toyoda K; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan., Dowlatshahi D; Division of Neurology, Department of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON, Canada., Demchuk AM; Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Khatri P; Department of Neurology, Yale School of Medicine, New Haven, CT, USA., Steiner T; Department of Neurology, Varisano Klinikum Frankfurt Höchst, Frankfurt, Germany; Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany., Bath PM; Stroke Trials Unit, Mental Health & Clinical Neuroscience, Queens Medical Centre, University of Nottingham, Nottingham, UK., Audebert HJ; Department of Neurology and Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Berlin, Germany., Vagal A; Department of Radiology, University of Cincinnati, Cincinnati, OH, USA., Yoshimura S; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan., Mayer SA; New York Medical College, Valhalla, NY, USA., Wang LL; Department of Radiology, University of Cincinnati, Cincinnati, OH, USA., Sabagha N; Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA., Mocco JD; Department of Neurosurgery, Icahn School of Medicine, Mount Sinai Health System, New York, NY, USA., Molina C; Department of Neurology, Stroke Unit, Vall d'Hebron University Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain., Aviv R; Department of Radiology, Radiation Oncology and Medical Physics, University of Ottawa, Ottawa, ON, Canada., Stinson E; Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA., Quadri SA; Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA., Carrozzella J; Department of Radiology, University of Cincinnati, Cincinnati, OH, USA., Huynh T; Department of Radiology, Mayo Clinic, Jacksonville, FL, USA., Phan A; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA., Beall J; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA., Davis I; Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA., Sakai N; Department of Neurosurgery, Kobe City Medical Center General Hospital, Hyogo, Japan., Ohta T; Department of Neurosurgery, Kobe City Medical Center General Hospital, Hyogo, Japan., Yokosawa M; Department of Neurosurgery, Iwate Prefectural Central Hospital, Morioka, Japan., Hara T; Department of Neurosurgery, Toranomon Hospital, Tokyo, Japan., Sangha N; Department of Neurology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA., Morita K; Department of Cerebrovascular Medicine, Niigata City General Hospital, Niigata, Japan., Dominc Tse MY; University of British Columbia, Vancouver, BC, Canada., Streib CD; Department of Neurology, University of Minnesota, Minneapolis, MN, USA., Miyashita F; Division of Neurology, Kagoshima City Hospital, Kagoshima, Kagoshima, Japan., Silva Y; Hospital Universitari de Girona, Dr Josep Trueta, IDIBG, Girona, Spain., Nagakane Y; Department of Neurology, Kyoto Second Red Cross Hospital, Kyoto, Japan., Gheorghiu T; Department of Neurology, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Sun CH; Neuroscience Institute, The Queen's Medical Center, Honolulu, Hawaii., Hirano T; Department of Stroke and Cerebrovascular Medicine, Kyorin University School of Medicine, Tokyo, Japan., Poli S; Department of Neurology and Stroke and Hertie-Institute for Clinical Brain Research University of Tübingen, Tübingen, Germany., Izumo T; Department of Neurosurgery, Gifu University Graduate School of Medicine, Nagasaki, Japan., Fukuda-Doi M; Department of Data Science, National Cerebral and Cardiovascular Center, Osaka, Japan., Ihara M; Department of Neurology, National Cerebral and Cardiovascular Center, Osaka, Japan., Koga M; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan., Buck B; University of Alberta, Edmonton, AB, Canada., Walsh KB; Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA., Spokovny I; Department of Neurology, Sutter Health, Mills Peninsula Medical Center, Burlingame, CA USA., Grotta JC; Memorial Hermann Hospital-Texas Medical Center, Houston, TX, USA.
Corporate Authors: FASTEST Investigators
Source: Lancet (London, England) [Lancet] 2026 Feb 21; Vol. 407 (10530), pp. 773-783. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article; Clinical Trial, Phase III; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.
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