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Impact of venetoclax trough levels on safety and efficacy in the treatment of acute myeloid leukemia.

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Title: Impact of venetoclax trough levels on safety and efficacy in the treatment of acute myeloid leukemia.
Authors: Hayashi H; Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan., Yamagiwa T; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan., Kanda J; Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan. jkanda16@kuhp.kyoto-u.ac.jp., Ishikawa T; Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan., Sawa M; Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan., Miyahara Y; Department of Hematology, Kyoto City Hospital, Kyoto, Japan., Tachibana T; Department of Hematology and Oncology, Kanagawa Cancer Center, Yokohama, Japan., Watanabe M; Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan., Ueda Y; Department of Hematology, Kurashiki Central Hospital, Kurashiki, Japan., Tsutsumi Y; Department of Hematology, Japanese Red Cross Society Kyoto Daini Hospital, Kyoto, Japan., Imada K; Department of Hematology, Japanese Red Cross Osaka Hospital, Osaka, Japan., Fujiwara SI; Division of Hematology, Jichi Medical University, Shimotsuke, Japan., Toubai T; Division of Hematology and Cell Therapy, Yamagata University Hospital, Yamagata, Japan., Yoshifuji K; Department of Hematology, Institute of Science Tokyo, Tokyo, Japan., Hirata H; Department of Hematology, Kansai Electric Power Hospital, Osaka, Japan., Kawabata H; Department of Hematology, NHO Kyoto Medical Center, Kyoto, Japan., Tsuji M; Department of Hematology, Japanese Red Cross Otsu Hospital, Otsu, Japan., Wakita S; Department of Hematology, Nippon Medical School, Tokyo, Japan., Yokoyama H; Division of Clinical Oncology/Hematology, Jikei University School of Medicine, Tokyo, Japan., Kitano T; Department of Hematology, Medical Research Institute Kitano Hospital, Osaka, Japan., Murai K; Department of Hematology, Iwate Prefectural Central Hospital, Morioka, Japan., Kataoka Y; Department of Hematology, Ikeda City Hospital, Ikeda, Japan., Kawata E; Department of Hematology, Matsushita Memorial Hospital, Moriguchi, Japan., Kimura SI; Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan., Yamamoto R; Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan., Miyao K; Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan., Nakayama D; Department of Hematology, Kyoto City Hospital, Kyoto, Japan., Izumi A; Department of Hematology and Oncology, Kanagawa Cancer Center, Yokohama, Japan., Kawata T; Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan., Onda Y; Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan., Sakamoto T; Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan., Mizumoto C; Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan., Kitawaki T; Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan., Yamashita K; Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan., Yonezawa A; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan.; Division of Integrative Clinical Pharmacology, Faculty of Pharmacy, Keio University, Tokyo, Japan., Kawakami T; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan., Nakagawa S; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan., Taniguchi R; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan., Terada T; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan., Takaori-Kondo A; Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan.
Source: Scientific reports [Sci Rep] 2026 Feb 07; Vol. 16 (1). Date of Electronic Publication: 2026 Feb 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Impact of venetoclax trough levels on safety and efficacy in the treatment of acute myeloid leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Hayashi+H%22">Hayashi H</searchLink>; Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yamagiwa+T%22">Yamagiwa T</searchLink>; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kanda+J%22">Kanda J</searchLink>; Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan. jkanda16@kuhp.kyoto-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Ishikawa+T%22">Ishikawa T</searchLink>; Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Sawa+M%22">Sawa M</searchLink>; Department of Hematology and Oncology, Anjo Kosei Hospital, Anjo, Japan.<br /><searchLink fieldCode="AU" term="%22Miyahara+Y%22">Miyahara Y</searchLink>; 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Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yamashita+K%22">Yamashita K</searchLink>; Department of Hematology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yonezawa+A%22">Yonezawa A</searchLink>; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan.; Division of Integrative Clinical Pharmacology, Faculty of Pharmacy, Keio University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kawakami+T%22">Kawakami T</searchLink>; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Nakagawa+S%22">Nakagawa S</searchLink>; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Taniguchi+R%22">Taniguchi R</searchLink>; 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